Analysis of the toxicological effects of phthalate esters on testes by administration, culture and transplantation methods

邻苯二甲酸酯在消费品生产过程中广泛用作增塑剂，已知对睾丸有毒性影响。本研究以邻苯二甲酸二丁酯（DBP）和邻苯二甲酸二异丁酯（DiBP）为材料，采用不同的方法研究了它们对睾丸的毒理学作用机制。因此，DBP的作用类似于雌激素，并可能通过激活雌激素受体诱导生精细胞凋亡。另一方面，DiBP诱导生精细胞凋亡，可能不依赖于雌激素介导的活性。

Phthalate esters, widely used as a plasticizer in the manufacturing process of consumer products, are known to affect testes toxicologically. In the present study, di(n-butyl) phthalate(DBP) and di-iso-butyl phthalate(DiBP) which belong to phthalate esters, are used as materials, and the mechanism of their toxicological effects on testes are investigated by some different methods. As a result, DBP acts like an estrogen, and induces spermatogenic cell apoptosis, probably by activating estrogen receptors. On the other hand, DiBP induces spermatogenic cell apoptosis, probably independent of estrogen-mediated activity.