Preparation of new chiral building blocks and their practical use in the enantioselective total synthesis of bioactive polycyclic natural products

新型手性结构单元的制备在具有多种结构的重要天然有机化合物（天然产物）的对映选择性全合成中具有优势。本研究开发了利用酶或手性催化剂催化制备手性结构单元的方法，并成功地应用于天然产物的对映选择性全合成，包括首次合成。这些手性结构单元及其制备方法将用于其他天然产物的全合成。

Preparation of new chiral building blocks has advantage in the enantioselective total synthesis of naturally occurring important organic compounds (natural products) possessing diverse structures. In this research project, preparation methods of chiral building blocks via the catalysis with enzymes or chiral catalysts have been developed and they have been successfully applied to the enantioselective total synthesis of natural products including first syntheses. The chiral building blocks as well as their preparation methods will be used in the total synthesis of other natural products.