Research on the design and synthesis of chiral NHC pincer ligands and their utility for asymmetric catalysis

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A new chiral N-heterocyclic carbene (NHC) pincer-type ligand was synthesized. Its cationic platinum complex catalyzed an enantioselective cycloisomerization of a 1,5-ene-yne. A new preparation method of imidazolinium salts from the corresponding thioureas was developed. An asymmetric epoxidation catalyzed by a new iron (III) complex of a chiral C2-symmetric pincer-type ligand was discovered. Imidazolinium salts, precursors of chiral C2-symmetric NHC pincer-type ligands, were synthesized in high yields but were found to be unstable and difficult to convert to the corresponding transition metal complexes.