Development of hybrid domino reactions via multi-chemical species and the synthetic application

共轭亚胺作为共轭p-体系的杂化型多米诺自由基反应是通过各种类型的化学物种如自由基、离子和有机金属物种的途径而发展起来的。通过环境友好的氧化和自由基离子多米诺反应，开发了高效的高功能化产品的合成方法，这两个反应都是通过大气中的氧气和适当的亲电剂捕获中间体来进行的。特别是，我们能够分离出意想不到的反应中间体，从而成功地开发了一种强大的合成方法，只需一次操作就可以合成各种类型的多功能和潜在的化合物。

Hybrid-type domino radical reactions of conjugated imine as a conjugated p-system were newly developed via the route involving various types of chemical species such as radical, ion, and organometallic species. Efficient synthetic methodology for highly functionalized products was developed via environmentally benign oxidation and radical-ionic domino reaction both of which proceeded via trapping the intermediates by atmospheric oxygen and appropriate electrophiles. Particularly, we were able to isolate unexpected reaction intermediates and thus succeeded in the development of powerful synthetic methods for various types of versatile and potential compounds by only one-manipulation.