Comprehensive Analysis of the mechanism involved in changes of thermoregulatory responses during dehydration

脱水是一个恶化自主体温调节反应的因素，可导致中暑。然而，核心机制仍不清楚。此外，我们不知道脱水对行为体温调节的影响。在本研究中，我们澄清了下丘脑的正中视前核是重要的血浆渗透压的受体网站，它抑制了正中视前核（中央的热接收网站）的热接收。小鼠的热逃逸/寻冷行为在脱水条件下受到抑制，脱水的人对热的热感觉也降低。这些结果提示了中暑的可能机制。

Dehydration is a factor deteriorating autonomic thermoregulatory responses, which could induce heat stroke. However, the central mechanism remains unclear yet. Moreover, we do not know about the influence of dehydration on behavioral thermoregulation. In the present study, we clarified that the median preoptic nucleus in the hypothalamus is important as the receptor site of plasma osmolality, and it suppresses thermal reception of the median preoptic nucleus(thermal reception site in the central). The heat escape/cold seeking behavior in mice is suppressed in the condition of dehydration, and thermal sensation to heat was also decreased in dehydrated humans. These results indicate a possible mechanism involved in heat stroke.