Analysis of changes in body temperature rhythm during fasting

禁食期间体温节律变化分析

• 批准号: 14570058
• 负责人: NAGASHIMA Kei
• 金额: $ 2.3万
• 依托单位: OSAKA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570058/
• 关键词: body temperature; metabolism; circadian rhythm; Vagus nerve; SCN; heat loss; homeostasis; food deprivation; 迷走神経; 生物時計; 体温; 低体温; 熱産生; 尾部血流

It is well known that body temperature (T_b) follows a circadian rhythm. Despite recent advance in knowledge of thermoregulation, we know only a little about the mechanism of the T_b rhythm. In this symposium, we show several evidences proving that i) the prime mechanism for the circadian T_b rhythm is a change in characteristics of thermoregulatory processes according to circadian phases, ii) clock genes and the suprachiasmatic nucleus are involved in the mechanism.T_b rhythm during fasting. In ad-lib feeding rats, T_b rhythm was linked with heat production rhythm. Moreover, tail surface temperature reflecting active heat loss also changed linearly with the T_b rhythm. Thus it is thought that heat production dominantly determines the T_b rhythm in fed condition. Although heat production decreased and its circadian amplitude was blunted during 3-day fasting, the T_b rhythm was well maintained. Moreover, the tail temperature decreased greatly in the active phase. These results suggest that animals control their circadian T_b rhythm by modulating thermoregulatory responses, which depends on feeding and/or nutritional states.

众所周知，体温（T_B）遵循昼夜节律。尽管近年来对体温调节的认识有了很大的进展，但我们对T_B节律的机制仍知之甚少。在本次研讨会上，我们展示了几个证据，证明i）昼夜T_b节律的主要机制是体温调节过程的特征随昼夜节律的变化，ii）生物钟基因和视交叉上核参与了这一机制。自由进食大鼠T_B节律与产热节律相联系。反映主动热损失的尾表面温度也随T_B节律呈线性变化。因此认为，在进食状态下，产热是决定T_B节律的主要因素。禁食3天后，虽然产热减少，昼夜幅度变钝，但T_B节律维持良好。此外，在活跃期，尾部温度大大降低。这些结果表明，动物通过调节体温调节反应来控制其昼夜T_B节律，而体温调节反应取决于进食和/或营养状态。

项目成果

Konishi, M., Nagashima, K., Asano, K., Kanosue, K.: "Attenuation of metabolic heat production and cold-escape/warm-seeking behavior during a cold exposure following systemic salt loading in rats."Journal of Physiology. 551. 713-720 (2003)

Konishi, M.、Nagashima, K.、Asano, K.、Kanosue, K.：“大鼠全身盐负荷后寒冷暴露期间代谢产热和避冷/寻暖行为的减弱。”生理学杂志

永島 計: "Effects of fasting on thermoregulatory responses and the daily oscillations in rats"American Journal of Physiology. 284(1). R1486-R1493 (2003)

Kei Nagashima：“禁食对大鼠体温调节反应和日常振荡的影响”美国生理学杂志 284(1) (2003)。

小西正博 他: "Attenuation of metabolic heat production and cold-escape/warm-seeking behaviour during a cold exposure following systemic salt loading in rats"Journal of Physiology. 551. 713-720 (2003)

Masahiro Konishi 等人：“大鼠全身盐负荷后寒冷暴露期间代谢产热和避冷/寻暖行为的减弱”生理学杂志 551. 713-720 (2003)。

小西 正博: "Attenuation of metabolic heat production and cold-escape/ warm-seeking behaviour during a cold exposure following systemic salt loading in rats"Journal of Physiology. 551(2). 713-720 (2003)

Masahiro Konishi：“大鼠全身盐摄入后冷暴露期间代谢产热和避冷/寻暖行为负荷的减弱”生理学杂志 551(2) (2003)。

Nagashima, K., Nakai, S., Matsue, K., Konishi, M., Tanaka, M., Kanosue, K.: "Effects of fasting on thermoregulation processes and the daily oscillations in rats."American Journal of Physiology. 284. R1486-R1493 (2003)

Nagashima, K.、Nakai, S.、Matsue, K.、Konishi, M.、Tanaka, M.、Kanosue, K.：“禁食对大鼠体温调节过程和日常波动的影响。”美国生理学杂志。