Visualizing the dynamics of senescence response in vivo

细胞衰老一直被认为是控制肿瘤抑制和衰老的重要机制。然而，由于细胞衰老主要是在体外研究的，因此尚不清楚细胞衰老是否确实发生在体内。为了解决这个问题，在这里，我们开发了一个系统来可视化体内衰老反应的动态，特别是在活体动物的背景下。这种方法结合基因敲除小鼠研究，揭示了体内细胞衰老的生物学作用。

Cellular senescence has long been considered as an important mechanism controlling tumor suppression and aging. However because cellular senescence had been studied mainly in vitro, it was unclear whether cellular senescence indeed occurs in vivo. To circumvent this problem, here we developed a system to visualize the dynamics of senescence response in vivo, especially in the context of living animal. This approach, in comjunction with the knockout mice studies, unveils biological roles of cellular senescence in vivo.