Novel C-terminus-specific functions of the APC protein

点击翻译按钮获取中文摘要

APC(adenomatous polyposis coli)was originally identified as a tumor suppressor protein. In the present study, we investigated functions of the APC regions except for the βcatenin-binding domain. Systemic behavior tests revealed schizophrenia-like behavior disorders of APC1638T mice which lack the C-terminus of APC. APC1638T mice showed morphological abnormalities of the hippocampal pyramidal neuron spines and conduction defects of the synapses. Also, distributions of monoamines in the APC1638T mouse brain altered. These disorders of APC1638T mice may cause their schizophrenia-like behavior.