Clinocopathological analysis of HTLV-I associated genes of HBZ and tax in the tumor genesis of ATLL

HBZ和tax的HTLV-I相关基因在ATLL肿瘤发生中的临床病理学分析

• 批准号: 20390104
• 负责人: KOICHI Ohshima
• 金额: $ 12.73万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390104/
• 关键词: ウイルス; 病理学; ATLL; HTLV-I; 腫瘍; HBZ; HTLV-1

Adult T-cell leukemia/lymphoma (ATLL) is a T-cell malignancy associated with human T-cell leukemia virus type 1 (HTLV-1). The HTLV-1 provirus genome has the pX region which encodes tax and HTLV-1 basic leucine zipper factor (HBZ). The previous studies have reported that the tax gene is expressed in few ATLL cases, but the HBZ gene in all ATLL cases. In this study, HBZ-expression was demonstrated in all cases of ATLL cell line and ATLL model mouse, and human ATLL cases. However, Tax expression was rare. In addition,we analyzed the expression of FOXP3, a key molecule of regulatory T cells. The expression was detected in about one third of ATLL. And FOXP3 expression is associated with an immunosuppressive state.

成人T细胞白血病/淋巴瘤(ATLL)是一种与人类T细胞白血病病毒1型(HTLV-1)相关的T细胞恶性肿瘤。HTLV-1前病毒基因组含有编码Tax和HTLV-1碱性亮氨酸拉链因子(HBZ)的Px区。以往的研究已报道，TAX基因在少数ATL病例中表达，而HBZ基因在所有ATL病例中表达。在本研究中，HBZ-在所有ATLL细胞系和ATLL模型小鼠以及人类ATLL病例中均有表达。然而，税收的表述却很少见。此外，我们还分析了调节性T细胞的关键分子FOXP3的表达。在约三分之一的ATLL中检测到该表达。FOXP3的表达与免疫抑制状态有关。

项目成果

Histological characteristics of 21 Papua New Guinean children with high-grade B-cell lymphoma, which is frequently associated with EBV infection.

21 名巴布亚新几内亚高级别 B 细胞淋巴瘤儿童的组织学特征，这种淋巴瘤通常与 EBV 感染相关。

• 发表时间: 2008
• 期刊: Pathol Int. 58(11)
• 作者: Nomura Y;Lavu EK;Muta K;Niino D;Takeshita M;Hirose S;Nakamura S;Yoshino T;Kikuchi M;Ohshima K
• 通讯作者: Ohshima K

Regression of rectal mucosa-associated lymphoid tissue (MALT) lymphoma after antibiotic treatments

• DOI: 10.1111/j.1440-1827.2010.02538.x
• 发表时间: 2010-06-01
• 期刊: PATHOLOGY INTERNATIONAL
• 影响因子: 2.2
• 作者: Niino, Daisuke;Yamamoto, Kouhei;Ohshima, Koichi
• 通讯作者: Ohshima, Koichi

Periostin and bone marrow fibrosis

• DOI: 10.1007/s12185-008-0095-2
• 发表时间: 2008-07-01
• 期刊: INTERNATIONAL JOURNAL OF HEMATOLOGY
• 影响因子: 2.1
• 作者: Oku, Eijiro;Kanaji, Taisuke;Okamura, Takashi
• 通讯作者: Okamura, Takashi

Characterization of de novo diffuse large B-cell lymphoma with a translocation of c-myc and immunoglobulin genes.

具有 c-myc 和免疫球蛋白基因易位的从头弥漫性大 B 细胞淋巴瘤的特征。

• 发表时间: 2008
• 期刊: Leuk Res. 32
• 作者: Kikuchi A;et al.
• 通讯作者: et al.

rray comparative genomic hybridization analysis of PTCL-U reveals a distinct subgroup with genetic alterations similar to lymphoma-type adult T-cell leukemia/lymphoma.

PTCL-U 的射线比较基因组杂交分析揭示了一个独特的亚组，其遗传改变类似于淋巴瘤型成人 T 细胞白血病/淋巴瘤。

• 发表时间: 2009
• 期刊: Clin Cancer Res. 1;15(1)
• 作者: Nakagawa M;Nakagawa-Oshiro A;Karnan S;Tagawa H;Utsunomiya A;Nakamura S;Takeuchi I;Ohshima K;Seto M
• 通讯作者: Seto M