Analysis and its significance of multifunction of staphylococcal enterotoxin family
Analysis and its significance of multifunction of staphylococcal enterotoxin family
批准号:
20390122
负责人:
NAKANE Akio
金额:
$9.65万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
We investigated roles of staphylococcal enterotoxin family molecules in infection, emesis and diarrhea.(1) TSST-1 played an important role in pathogenesis of Staphylococcus aureus infectio(2) Among SEA, SEC and TSST-1, SEA and SEC showed emesis-inducing activity but none of them revealed diarrhea-inducing activity.(3) TSST-1 suppressed autophagy formation in epithelial cells.(4) Vaccination with recombinant clumping factor A induced acquired host resistance to S. aureus infection in mice, depending on IL-17.
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黄色ブドウ球菌接着因子による感染予防効果
金黄色葡萄球菌粘附因子的预防感染作用
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[成田浩司, 胡東良, 重茂克彦, 品川邦汎, 中根明夫]
通讯作者:
中根明夫
Vaccination with nontoxic mutant staphylococcal enterotoxin A, D227A, protects against enterotoxin-induced emesis in house musk shrews
无毒突变葡萄球菌肠毒素 A、D227A 疫苗接种可防止家麝鼩发生肠毒素引起的呕吐
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Hu, D.-L., et.al.]
通讯作者:
et.al.
Identification and characterization of two novel staphylocoCcAl enteroloxins types S and T
两种新型葡萄球菌 CcAl 肠毒素 S 型和 T 型的鉴定和表征
DOI:
--
发表时间:
2008
期刊:
Infect. Immun 76
影响因子:
--
作者:
[Ono H. Hu DL, Nakane A, et.al.]
通讯作者:
et.al.
Comparative prevalence of superantigenic toxin genes in methicillin-resistant and methicillin-susceptible Staphylococcus aureus isolates
耐甲氧西林和甲氧西林敏感金黄色葡萄球菌分离株中超抗原毒素基因的比较流行率
DOI:
--
发表时间:
2008
期刊:
J.Med.Microbiol 57(9)
影响因子:
--
作者:
[Hu, D.-L., Omoe, K., Inoue, F., Kasai,T., Yasujima, M., Shinagawa, K. and Nakane, A.]
通讯作者:
A.
Protective effect of glutathione S-transferase-fuzed mutant staphylococcal enterotoxin C against Staphylococcus aureus-induced bovine mastitis
谷胱甘肽S-转移酶融合突变型葡萄球菌肠毒素C对金黄色葡萄球菌引起的牛乳腺炎的保护作用
DOI:
--
发表时间:
2010
期刊:
Vet Immunol Immunopath
影响因子:
--
作者:
[Cui J-C, Zhang B-J, Lin Y-C, Wang Q-K, Qian A-D, Nakane A, Hu D-L, Tong G-Z]
通讯作者:
Tong G-Z
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Application of adipose tissue-derived mesenchymal stem cells to antimicrobial therapy
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批准号:23659217
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依托单位:
Is the superantigenic activity required for the emetic activity of staphylococcal enterotoxin A
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资助金额:$10.98万
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负责人:NAKANE Akio
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依托单位:
The control of bacterial infectious diseases by the hamony of immune system and nerve system
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批准号:13670261
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依托单位:
The control of bacterial infectious diseases by the orchestra of immune system and nerve system
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资助金额:$2.11万
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财政年份:1998
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负责人:NAKANE Akio
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依托单位:
The crosstalk of immune system and nerve system in host defense to bacterial infections
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批准号:08670297
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.28万
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财政年份:1996
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负责人:NAKANE Akio
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依托单位:
The network of immune system and nerve system in host defense to bacterial infections
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批准号:05670245
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.41万
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依托单位:
Development of the therapy of severe bacterial infectious dieases by blockade of cytokine cascade
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批准号:03557021
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$6.78万
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财政年份:1991
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负责人:NAKANE Akio
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依托单位:
国内基金
海外基金
金葡菌TSST-1经色氨酸-AcCoA代谢乙酰化mTORC1 Raptor抑制VSMC自噬促进动脉粥样硬化
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批准号:82172281
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项目类别:面上项目
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资助金额:55万元
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批准年份:2021
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负责人:刘庆中
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依托单位:
TSST-1超抗原T细胞免疫识别的研究
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批准号:39600134
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依托单位: