Development of predictive diagnostic method for autoimmune diseases on the basis of the mechanism of peripheral self-tolerance induction

基于外周自身耐受诱导机制的自身免疫性疾病预测诊断方法的开发

• 批准号: 20390168
• 负责人: IWATANI Yoshinori
• 金额: $ 8.65万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390168/
• 关键词: 発症予知; 診断法; 遺伝子多型; 一塩基多型; 自己免疫疾患; 甲状腺; 重症度; 末梢性自己寛容; 制御性T細胞; 発生制御因子; GITR; FOXP3; 甲状線; Foxel; GITRL; HHEX

We tried to find the genetic polymorphisms useful for the predictive diagnosis of the development or the prognosis of autoimmune thyroid disease on the basis of the possibilities that the induction factors for peripheral self-tolerance and the regulatory factors for target organ development are related to the pathogenesis of autoimmune thyroid disease (AITD). As a result, we found that SNPs of GITR, Foxp3, HHHEX, Foxel and CTLA-4 were related to the prognosis or the development of AITD, and were useful for the predictive diagnostic methods for AITD.

本研究试图从自身免疫性甲状腺疾病（AITD）的发病机制和外周自身免疫耐受的诱导因子及靶器官发育的调控因子的可能性出发，寻找可用于自身免疫性甲状腺疾病（AITD）发生发展及预后预测的基因多态性。结果表明，GITR、Foxp 3、HHHEX、Foxel和CTLA-4基因的SNPs与AITD的预后或发展相关，可作为AITD的预测性诊断方法。

项目成果

Decrease of intrathyroidal CD161+Valpha24+Vbetall+NKT cellsin Graves' disease.

格雷夫斯病中甲状腺内 CD161 Valpha24 Vbetall NKT 细胞减少。

• 发表时间: 2008
• 期刊: Endocrine Journal 55
• 作者: Watanabe M;et al
• 通讯作者: et al

Arteriosclerosis obliterans associated with antti-cardiolipinantibody /{beta}2-glycoprotein I antibodies as a strong riskfactor for ischaemic heart disease in patients with systemiclupus erythematosus.

与抗心磷脂抗体/β2-糖蛋白 I 抗体相关的动脉硬化闭塞症是系统性红斑狼疮患者缺血性心脏病的强危险因素。

• 发表时间: 2008
• 期刊: Rheumatology (Oxford) 47
• 作者: Noi ima J;et al
• 通讯作者: et al

Involvement of functional polymorphisms in the TNFA gene in the pathogenesis of autoimmune thyroid diseases and production of anti-TSH receptor antibody.

TNFA 基因的功能多态性参与自身免疫性甲状腺疾病的发病机制和抗 TSH 受体抗体的产生。

• 发表时间: 2009
• 期刊: Clin Exp Immunol 156(2)
• 作者: Inoue;N.;Watanabe;M.;Nanba;T.;Wada;M.;Akamizu;T.;Iwatani;Y.
• 通讯作者: Y.

Association of the -31C/T functional polymorphism in the interleukin-1β gene with the intractability of Graves' disease and the proportion of Th17 cells.

IL-1β基因-31C/T功能多态性与Graves病难治性及Th17细胞比例的关系

• 发表时间: 2009
• 作者: Watanabe;M.;Hayashi;F.;Nanba;T.;Inoue;N.;Akamizu;T.;Iwatani;Y.
• 通讯作者: Y.

Expression of nestin mRNA is a differentiation marker in thyroid tumors.

• DOI: 10.1016/j.canlet.2009.02.006
• 发表时间: 2009-07
• 期刊: Cancer letters
• 影响因子: 9.7
• 作者: Hiroya Yamada;T. Takano;Yasuhiro Ito;F. Matsuzuka;A. Miya;Kaoru Kobayashi;H. Yoshida;Mikio Watanabe;Y. Iwatani;A. Miyauchi