Development of predictive diagnostic method for autoimmune diseases on the basis of the mechanism of peripheral self-tolerance induction

根据自身免疫性甲状腺疾病(AITD)发病机制中存在的外周自身耐受诱导因子和靶器官发育调控因子的可能性，我们试图寻找对自身免疫性甲状腺疾病(AITD)的发生、发展或预后进行预测诊断的基因多态性。结果发现，GITR、Foxp3、HHHEX、Foxel和CTLA-4基因SNP与AITD的预后或发展有关，可作为AITD的预测诊断方法。

We tried to find the genetic polymorphisms useful for the predictive diagnosis of the development or the prognosis of autoimmune thyroid disease on the basis of the possibilities that the induction factors for peripheral self-tolerance and the regulatory factors for target organ development are related to the pathogenesis of autoimmune thyroid disease (AITD). As a result, we found that SNPs of GITR, Foxp3, HHHEX, Foxel and CTLA-4 were related to the prognosis or the development of AITD, and were useful for the predictive diagnostic methods for AITD.