Analysis and risk assessment of diffuse gastric cancer based on inflammation-induced epigenetic alterations
Analysis and risk assessment of diffuse gastric cancer based on inflammation-induced epigenetic alterations
批准号:
20390210
负责人:
SHINOMURA Yasuhisa
金额:
$11.9万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
In the current study, we have analyzed for aberrant DNA methylation which is associated with Helicobacter pylori (H.pylori) induced gastric carcinogenesis. We have shown evidences that both CpG island hypermethylation of cancer-related genes and global hypomethylation occurs in premalignant lesions of diffuse gastric cancer. In addition, through genome-wide screening, we have identified aberrant DNA methylation of novel gastric cancer-related genes and microRNAs. Functional analysis revealed that these are candidate gastric cancer suppressor genes, and DNA methylation analysis in clinical samples suggested that these could be useful risk markers of gastric cancer.
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Blockade of insulin-like growth factor-I receptor is a useful anticancer therapeutic for esophageal squamous cell carcinoma.
阻断胰岛素样生长因子-I 受体是治疗食管鳞状细胞癌的有效抗癌疗法。
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Yamamoto H., et al.]
通讯作者:
et al.
Inflammation-related aberrant patterns of DNA methylation : detection and role in epigenetic deregulation of cancer cell transcriptome. Inflammation and Cancer. Methods and Protocols : Volume 2 : Molecular Analysis and Pathways. Methods in Molecular Biolo
炎症相关的 DNA 甲基化异常模式:癌细胞转录组表观遗传失调的检测和作用。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Suzuki H, Toyota M, Kondo Y, Shinomura Y.]
通讯作者:
Shinomura Y.
Anti-tumor Efficacy of anti-FGFR1 monoclonal antibody for human hepatoma Cells.
抗FGFR1单克隆抗体对人肝癌细胞的抗肿瘤功效。
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Muroyama R, Kato N, Otsuka M, Chang JH, Omata M., Muroyama R, Sasaki S]
通讯作者:
Sasaki S
DOI:
10.1158/1078-0432.ccr-08-3336
发表时间:
2009-07-01
期刊:
CLINICAL CANCER RESEARCH
影响因子:
11.5
作者:
[Nojima, Masanori, Maruyama, Reo, Shinomura, Yasuhisa]
通讯作者:
Shinomura, Yasuhisa
DOI:
10.1159/000320453
发表时间:
2011-01
期刊:
Digestion
影响因子:
3.2
作者:
[Eiichiro Yamamoto;Hiromu Suzuki;H. Takamaru;Hiroyuki Yamamoto;M. Toyota;Y. Shinomura]
通讯作者:
Eiichiro Yamamoto;Hiromu Suzuki;H. Takamaru;Hiroyuki Yamamoto;M. Toyota;Y. Shinomura
共 48 条
Analysis of long non-coding RNAs that predict biological malignancy in GIST
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批准号:25670371
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2013
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负责人:SHINOMURA Yasuhisa
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依托单位:
Epigenomic analysis of gastrointestinal cancer stroma
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批准号:23659400
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2011
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负责人:SHINOMURA Yasuhisa
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依托单位:
Analysis of the abnormalities of microRNA and epigenome and the clinical application in gastroenterological cancers
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批准号:23390200
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.4万
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财政年份:2011
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负责人:SHINOMURA Yasuhisa
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依托单位:
Development of diagnostic methods of gastrointestinal cancer using integrated analysis of nuclear molecules
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批准号:18390221
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.03万
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财政年份:2006
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负责人:SHINOMURA Yasuhisa
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依托单位:
Interaction of proinflammatory cytokines and growth factors in gastric carcinogenesis
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批准号:14370181
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.45万
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财政年份:2002
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负责人:SHINOMURA Yasuhisa
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依托单位:
Effect of gain-of-function mutation of c-kit on apoptosis in gastrointestinal mesenchymal cells
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批准号:12670483
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.43万
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财政年份:2000
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负责人:SHINOMURA Yasuhisa
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依托单位:
Development of novel therapeutics targeting the function of intestinal cells of Cajal in gastrointestinal motility disorder
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批准号:11557042
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$8.45万
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财政年份:1999
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负责人:SHINOMURA Yasuhisa
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依托单位:
Role of gain-of-function mutations of c-kit gene on tumor development in gastrointestinal stromal tumor.
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批准号:10670471
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.05万
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财政年份:1998
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负责人:SHINOMURA Yasuhisa
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依托单位:
海外基金