Analysis and risk assessment of diffuse gastric cancer based on inflammation-induced epigenetic alterations

基于炎症诱导的表观遗传改变的弥漫性胃癌分析和风险评估

• 批准号: 20390210
• 负责人: SHINOMURA Yasuhisa
• 金额: $ 11.9万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390210/
• 关键词: 遺伝子診断; 遺伝子変異; メチル化; 前癌病変; H.pylori; H. pylori

In the current study, we have analyzed for aberrant DNA methylation which is associated with Helicobacter pylori (H.pylori) induced gastric carcinogenesis. We have shown evidences that both CpG island hypermethylation of cancer-related genes and global hypomethylation occurs in premalignant lesions of diffuse gastric cancer. In addition, through genome-wide screening, we have identified aberrant DNA methylation of novel gastric cancer-related genes and microRNAs. Functional analysis revealed that these are candidate gastric cancer suppressor genes, and DNA methylation analysis in clinical samples suggested that these could be useful risk markers of gastric cancer.

在目前的研究中，我们分析了与幽门螺杆菌（H.pylori）诱导的胃癌发生相关的异常DNA甲基化。我们有证据表明，癌相关基因的CpG岛高甲基化和整体低甲基化发生在弥漫性胃癌的癌前病变中。此外，通过全基因组筛选，我们发现了新型胃癌相关基因和microrna的异常DNA甲基化。功能分析表明，这些基因是胃癌抑制基因的候选基因，临床样品的DNA甲基化分析表明，这些基因可能是胃癌的有用危险标志物。

项目成果

Inflammation-related aberrant patterns of DNA methylation : detection and role in epigenetic deregulation of cancer cell transcriptome. Inflammation and Cancer. Methods and Protocols : Volume 2 : Molecular Analysis and Pathways. Methods in Molecular Biolo

炎症相关的 DNA 甲基化异常模式：癌细胞转录组表观遗传失调的检测和作用。

• 发表时间: 2009
• 作者: Suzuki H;Toyota M;Kondo Y;Shinomura Y.
• 通讯作者: Shinomura Y.

Blockade of insulin-like growth factor-I receptor is a useful anticancer therapeutic for esophageal squamous cell carcinoma.

阻断胰岛素样生长因子-I 受体是治疗食管鳞状细胞癌的有效抗癌疗法。

• 发表时间: 2008
• 作者: Yamamoto H.;et al.
• 通讯作者: et al.

Anti-tumor Efficacy of anti-FGFR1 monoclonal antibody for human hepatoma Cells.

抗FGFR1单克隆抗体对人肝癌细胞的抗肿瘤功效。

• 发表时间: 2008
• 作者: Muroyama R;Kato N;Otsuka M;Chang JH;Omata M.;Muroyama R;Sasaki S
• 通讯作者: Sasaki S

Role of DNA Methylation in the Development of Diffuse-Type Gastric Cancer

• DOI: 10.1159/000320453
• 发表时间: 2011-01
• 期刊: Digestion
• 影响因子: 3.2
• 作者: Eiichiro Yamamoto;Hiromu Suzuki;H. Takamaru;Hiroyuki Yamamoto;M. Toyota;Y. Shinomura

Genomic Screening for Genes Silenced by DNA Methylation Revealed an Association between RASD1 Inactivation and Dexamethasone Resistance in Multiple Myeloma

• DOI: 10.1158/1078-0432.ccr-08-3336
• 发表时间: 2009-07-01
• 期刊: CLINICAL CANCER RESEARCH
• 影响因子: 11.5
• 作者: Nojima, Masanori;Maruyama, Reo;Shinomura, Yasuhisa
• 通讯作者: Shinomura, Yasuhisa