Regulation of cardiac metabolism by Akt signaling

Akt是一种丝氨酸/苏氨酸蛋白激酶，位于pi3激酶的下游，调节多种细胞过程，包括细胞生长和葡萄糖代谢。本研究旨在探讨Akt信号在心脏代谢调控中的作用机制。我们发现Akt激活导致脂肪酸氧化下调，心脏中Akt通路下调导致收缩功能障碍。这些数据表明Akt在一定程度上通过调节心脏ATP合成来维持心脏功能。

Akt is a serine/threonine protein kinase that is situated downstream of PI3-kinase and regulates multiple cellular processes including cell growth and glucose metabolism. The purpose of the present study was to investigate the mechanism of metabolic regulation by Akt signaling in the heart. We found that Akt activation leads to downregulation of fatty acid oxidation and that downregulation of Akt pathway in the heart leads to contractile dysfunction. These data suggest that Akt maintains cardiac function in part through regulation of ATP synthesis in the heart.