Regulation of cardiac metabolism by Akt signaling

Akt 信号传导调节心脏代谢

• 批准号: 20390217
• 负责人: SHIOJIMA Ichiro
• 金额: $ 11.9万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390217/
• 关键词: Akt; 糖代謝; 脂肪酸代謝; 心不全

Akt is a serine/threonine protein kinase that is situated downstream of PI3-kinase and regulates multiple cellular processes including cell growth and glucose metabolism. The purpose of the present study was to investigate the mechanism of metabolic regulation by Akt signaling in the heart. We found that Akt activation leads to downregulation of fatty acid oxidation and that downregulation of Akt pathway in the heart leads to contractile dysfunction. These data suggest that Akt maintains cardiac function in part through regulation of ATP synthesis in the heart.

Akt是一种丝氨酸/苏氨酸蛋白激酶，位于PI 3-激酶的下游，调节多种细胞过程，包括细胞生长和葡萄糖代谢。本研究旨在探讨Akt信号在心脏代谢调控中的作用机制。我们发现Akt激活导致脂肪酸氧化的下调，并且心脏中Akt通路的下调导致收缩功能障碍。这些数据表明，Akt部分通过调节心脏中的ATP合成来维持心脏功能。

项目成果

Chronic doxorubicin cardiotoxicity is mediated by oxidative DNA damage-ATM-p53-apoptosis pathway and attenuated by pitavastatin through the inhibition of Rac1 activity

• DOI: 10.1016/j.yjmcc.2009.07.024
• 发表时间: 2009-11-01
• 期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
• 影响因子: 5
• 作者: Yoshida, Masashi;Shiojima, Ichiro;Komuro, Issei
• 通讯作者: Komuro, Issei

Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents

• DOI: 10.1172/jci40096
• 发表时间: 2010-05-01
• 期刊: JOURNAL OF CLINICAL INVESTIGATION
• 影响因子: 15.9
• 作者: Shimizu, Ippei;Minamino, Tohru;Komuro, Issei
• 通讯作者: Komuro, Issei

A crucial role of a high mobility group protein HMGA2 in cardiogenesis

• DOI: 10.1038/ncb1719
• 发表时间: 2008-05-01
• 期刊: NATURE CELL BIOLOGY
• 影响因子: 21.3
• 作者: Monzen, Koshiro;Ito, Yuzuru;Komuro, Issei
• 通讯作者: Komuro, Issei

Promotion of CHIP-Mediated p53 Degradation Protects the Heart From Ischemic Injury

• DOI: 10.1161/circresaha.109.214346
• 发表时间: 2010-06-11
• 期刊: CIRCULATION RESEARCH
• 影响因子: 20.1
• 作者: Naito, Atsuhiko T.;Okada, Sho;Komuro, Issei
• 通讯作者: Komuro, Issei

Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy.

• DOI: 10.1016/j.yjmcc.2009.08.028
• 发表时间: 2009-11
• 期刊: Journal of molecular and cellular cardiology
• 影响因子: 5
• 作者: Ikeda H;Shiojima I;Ozasa Y;Yoshida M;Holzenberger M;Kahn CR;Walsh K;Igarashi T;Abel ED;Komuro I
• 通讯作者: Komuro I