Regulation of cardiac function by insulin signaling

通过胰岛素信号调节心脏功能

• 批准号: 23390214
• 负责人: SHIOJIMA Ichiro
• 金额: $ 12.31万
• 依托单位: Kansai Medical University (2012-2013)Osaka University (2011)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390214/
• 关键词: インスリン; mTOR; 心不全; 糖代謝; 脂肪酸代謝; Akt

Insulin signaling regulates multiple cellular processes including glucose homeostasis and transcriptional/translational regulation. Our preliminary data showed that deletion of insulin receptor gene specifically in the adult heart results in impaired cardiac contractility. We therefore tried to explore the mechanistic basis for the regulation of cardiac function by insulin signaling.We found that Akt-mTOR pathway is specifically downregulated in the heart by insulin receptor gene deletion and activation of mTOR reverses the deleterious effect of insulin receptor knockout on contractile function. Our results suggest that insulin signaling in the heart regulates contractile function through Akt-mTOR branch.

胰岛素信号调节多种细胞过程，包括葡萄糖稳态和转录/翻译调节。我们的初步数据表明，成人心脏中胰岛素受体基因的特异性缺失会导致心脏收缩性受损。因此，我们试图探索胰岛素信号调节心脏功能的机制基础。我们发现Akt-mTOR通路在心脏中通过胰岛素受体基因缺失而特异性下调，mTOR的激活逆转了胰岛素受体敲除对收缩功能的有害影响。我们的研究结果表明，心脏中的胰岛素信号通过Akt-mTOR分支调节收缩功能。

项目成果

Ryanodine Receptor Type 2 Is Required for the Development of Pressure Overload-Induced Cardiac Hypertrophy

压力过载引起的心脏肥大的发生需要 2 型瑞尼定受体

• DOI: 10.1161/hypertensionaha.111.173500
• 发表时间: 2011-12
• 期刊: Hypertension
• 影响因子: 8.3
• 作者: Shiojima, Ichiro;Wang, Yuqi;Komuro, Issei;Ge, Junbo
• 通讯作者: Ge, Junbo

Short-term akt activation in cardiac muscle cells improves contractile function in failing hearts.

心肌细胞中的短期 akt 激活可改善衰竭心脏的收缩功能。

• DOI: 10.1016/j.ajpath.2012.08.020
• 发表时间: 2012
• 期刊: The American journal of pathology
• 作者: Shiojima,Ichiro;Schiekofer,Stephan;Schneider,JochenG;Belisle,Kurt;Sato,Kaori;Andrassy,Martin;Galasso,Gennaro;Walsh,Kenneth
• 通讯作者: Walsh,Kenneth

心臓インスリンシグナルによる心機能調節

心脏胰岛素信号调节心脏功能

• 发表时间: 2012
• 作者: Zou Y;Liang Y;Zhou N;Ma H;Guan A;Gong H;Sun A;Wang P;Niu Y;Jiang H;Takano H;Toko H;Yao A;Takeshima H;Akazawa H;Shiojima I;Wang Y;Komuro I;Ge J;塩島一朗
• 通讯作者: 塩島一朗