Brain substrates of and therapeutic approaches for motivational symptoms in schizophrenia and mood disorders : a near-infrared spectroscopy (NIRS) study

使用磁共振成像(MRI)、近红外光谱(NIRS)和脑磁图(MEG)研究了精神障碍患者动机症状的脑基础。前额叶皮质的体积和功能与健康受试者的主观嗜睡和疲劳、婴儿期的父母关系和合作个性有关，2)与精神分裂症的整体功能评估(GAF)、Sigma-1受体和儿茶酚胺-O-甲基转移酶(COMT)的DNA多态性有关，3)与进食障碍的临床症状相关，4)与双相情感障碍的负性失配潜伏期相关。这些结果表明，前额叶皮质是精神疾病中动机症状的大脑底物。

Brain substrates of motivational symptoms in psychiatric disorders were investigated using magnetic resonance imaging (MRI), near-infrared spectroscopy (NIRS), and magnetoencephalography (MEG). Prefrontal cortex volume and function correlated 1) with subjective sleepiness and fatigue, parental bonding in infancy, and cooperative personality in healthy subjects, 2) with global assessment of functioning (GAF), DNA polymorphism of sigma-1 receptor and catecholamine-O-methyl transferase (COMT) in schizophrenia, 3) with clinical symptoms in eating disorders, and 4) with mismatch negativity latency in bipolar disorder. These results suggest prefrontal cortex as brain substrates of motivational symptoms in psychiatric disorders.