Brain substrates of and therapeutic approaches for motivational symptoms in schizophrenia and mood disorders : a near-infrared spectroscopy (NIRS) study

利用磁共振成像（MRI）、近红外光谱（NIRS）和脑磁图（MEG）研究了精神障碍中动机症状的脑基质。前额叶皮质体积和功能与以下因素相关：1）主观嗜睡和疲劳，婴儿期父母关系，以及健康受试者的合作人格; 2）精神分裂症患者的整体功能评估（GAF），sigma-1受体和儿茶酚胺-O-甲基转移酶（COMT）的DNA多态性; 3）进食障碍患者的临床症状; 4）双相情感障碍患者的失匹配负波潜伏期。这些结果表明，前额叶皮层作为大脑基板的动机症状的精神障碍。

Brain substrates of motivational symptoms in psychiatric disorders were investigated using magnetic resonance imaging (MRI), near-infrared spectroscopy (NIRS), and magnetoencephalography (MEG). Prefrontal cortex volume and function correlated 1) with subjective sleepiness and fatigue, parental bonding in infancy, and cooperative personality in healthy subjects, 2) with global assessment of functioning (GAF), DNA polymorphism of sigma-1 receptor and catecholamine-O-methyl transferase (COMT) in schizophrenia, 3) with clinical symptoms in eating disorders, and 4) with mismatch negativity latency in bipolar disorder. These results suggest prefrontal cortex as brain substrates of motivational symptoms in psychiatric disorders.