NIRS and MEG study on brain mechanisms of social cognitive deficits in schizophrenia and mood disorders

NIRS 和 MEG 研究精神分裂症和情绪障碍社会认知缺陷的脑机制

• 批准号: 18390318
• 负责人: FUKUDA Masato
• 金额: $ 3.92万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390318/
• 关键词: near-infrared spectroscopy; magnetoencephalography; schizophrenia; mood disorders; social cognition

Objectives: Near-infrared spectroscopy (NIBS) is a recently developed technology that monitors cerebral blood volume changes noninvasively in bedside setting. NIRS has been increasingly employed in psychiatry such as functional neuroimaging studies of personality, aging, and psychiatric disorders. Characteristics of frontal lobe function were investigated using multichannel NIRS machines in schizophrenia, unipolar depression, and bipolar depression.Methods: Twenty-five patients with schizophrenia, eleven patients with unipolar depression, seventeen patients with bipolar depression, and their age- and sex-matched healthy subjects participated in the study after giving their written informed consents. Changes of oxy-hemoglobin concentration ( [oxy-Hb] ) were monitored every 0.1 s during a word fluency task and a finger-tapping task using two sets of 24-channel NIRS machines (Hitachi Medical Co.) with the probes placed on the subjects' frontal and the bilateral temporal regions.Results: Three psychiatric groups demonstrated different patterns of [oxy-Hb] changes from those in the control group during the word fluency task although their task performances were equal. The schizophrenic group was characterized by reduced [oxy-Hb] increase during the task period followed by [oxy-Hb] re-increase during the post-task period, the unipolar depression group by smaller [oxy-Hb] increase, and the bipolar depression group by comparable but delayed [oxy-Hb] increase.Conclusions: The observed differences of [oxy-Hb] changes suggest the characteristics in time courses of reactivity of frontal lobe function: inefficient, reduced, and preserved but delayed activation in schizophrenia, unipolar depression, and bipolar depression, respectively. NIRS has revealed detailed time-courses of frontal lobe activation, and can be employed as a clinical laboratory test for diagnosis and treatment of psychiatric disorders in the near future.

目的：近红外光谱（NIBS）是近年来发展起来的一种在床边无创监测脑血容量变化的技术。近红外光谱已越来越多地用于精神病学，如人格，衰老和精神疾病的功能神经影像学研究。方法：采用多通道近红外光谱仪对25例精神分裂症、11例单相抑郁症、17例双相抑郁症患者及其年龄、性别匹配的健康志愿者进行额叶功能的研究。在单词流畅性任务和手指敲击任务期间，使用两套24通道NIRS机器（Hitachi Medical Co.）每0.1秒监测氧合血红蛋白浓度（[oxy-Hb]）的变化。结果：3组精神病患者在完成词流畅性任务时，[oxy-Hb]的变化模式与对照组不同。精神分裂症组的特点是减少[oxy-Hb]增加在任务期间，然后[oxy-Hb]重新增加在任务后期间，单相抑郁症组的[oxy-Hb]增加较小，双相抑郁症组的[oxy-Hb]增加可比，但延迟increasing.Conclusions：观察到的差异[oxy-Hb]的变化表明额叶功能的反应性的时间进程的特点：在精神分裂症、单相抑郁症和双相抑郁症中，激活效率低下、减少和保留但延迟。近红外光谱已揭示了额叶激活的详细时间过程，并可在不久的将来用作诊断和治疗精神疾病的临床实验室检查。

项目成果

Relationship between age at onset and magnetic resonance image (MRI)-defined hyperintensities in mood disorders

情绪障碍中发病年龄与磁共振图像 (MRI) 定义的高信号之间的关系

• 发表时间: 2008
• 期刊: j Psychiatr Res 42
• 作者: Takahashi K;Oshima A;Ida I;Kumano H;Yuuki N;Fukuda M;Amanuma A;Endo K;Mikuni M
• 通讯作者: Mikuni M

近赤外線スペクトロスコピィ(NIRS)の精神疾患への応用

近红外光谱（NIRS）在精神疾病中的应用

• 发表时间: 2006
• 作者: Nagata;Y;福田正人
• 通讯作者: 福田正人

Comparison between mismatch negativity amplitude and magnetic mismatch field strength in normal adults

• DOI: 10.1016/j.biopsycho.2005.01.011
• 发表时间: 2006-01
• 期刊: Biological Psychology
• 影响因子: 2.6
• 作者: Noriko Kudo;K. Kasai;K. Itoh;I. Koshida;M. Yumoto;Masato Kato;S. Kamio;T. Araki;K. Nakagome;M. Fukuda;H. Yamasue;Haruyasu Yamada;O. Abe;N. Kato;A. Iwanami

Phonetic mismatch negativity predicts social skills acquisition in schizophrenia

• DOI: 10.1016/j.psychres.2006.02.010
• 发表时间: 2007-08-30
• 期刊: PSYCHIATRY RESEARCH
• 影响因子: 11.3
• 作者: Kawakubo, Yuki;Kamio, Satoru;Kasai, Kiyoto
• 通讯作者: Kasai, Kiyoto

Decreased cortical reactivity underlies subjective daytime light sleepiness in healthy subjects: A multichannel near-infrared spectroscopy study

• DOI: 10.1016/j.neures.2007.12.001
• 发表时间: 2008-03-01
• 期刊: NEUROSCIENCE RESEARCH
• 影响因子: 2.9
• 作者: Suda, Masashi;Sato, Toshimasa;Mikuni, Masahiko
• 通讯作者: Mikuni, Masahiko