Innovation of isolated pancreatic perfusion therapy for pancreas cancer

胰腺癌离体胰腺灌注治疗的创新

• 批准号: 20390331
• 负责人: MURATA Satoru
• 金额: $ 9.48万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390331/
• 关键词: インターベンショナルラジオロジ(IVR); 膵臓; 閉鎖循環; 灌流療法; 注入速度; 抗がん剤濃度; 膵浮腫; 膵癌; Drug delivery system; Interventional Radiology; maximum platinum concentration; concentration-time curve; blood concentration-time curve

As the result of anatomical research of the blood flow inside the pancreas of pigs, it was proved that the dorsal pancreatic artery is the most important artery in order to perfuse the anticancer agent because the arterial flow through the dorsal pancreatic artery reaches all over the pancreas among all the arterial flows. We have performed a percutaneous isolated pancreatic perfusion (PIPP). The leakage rate via the pancreatic circulation into the systemic circulation was only 2 %. Histopathological examinations showed no ischemic changes or other abnormalities in the liver, duodenum, small intestine, or colon. However, they showed edematous changes in the pancreas with in-flow rate of 120 mL/min or more. On the other side, there was no edematous change in the pancreas with 60 mL/min in-flow rate. To apply this innovative therapy for pancreas cancers, we need to investigate adequate in-flow rate of PIPP therapy.

作为猪胰腺内血流的解剖学研究的结果，证明了胰背动脉是灌注抗癌剂的最重要的动脉，因为在所有动脉流中，通过胰背动脉的动脉流到达整个胰腺。我们已经进行了经皮隔离胰腺灌注（PIPP）。通过胰循环进入体循环的渗漏率仅为2%。组织学检查显示肝脏、十二指肠、小肠或结肠无缺血性变化或其他异常。然而，它们显示胰腺水肿变化，流入速率为120 mL/min或更高。另一方面，在60 mL/min的流入速率下，胰腺中没有水肿变化。为了将这种创新疗法应用于胰腺癌，我们需要研究PIPP疗法的适当流入速率。

项目成果

Initial experience of transcatheter arterial chemoembolization during portal vein occlusion for unresectable hepatocellular carcionoma with marked arterioportal shunts.

门静脉闭塞治疗伴有明显动脉门静脉分流的不可切除肝细胞癌时经导管动脉化疗栓塞的初步经验。

• 发表时间: 2009
• 期刊: European Radiology Vol.19 No.8
• 作者: Murata S.;et al
• 通讯作者: et al

Comparative study of transcatheter renal arterial embolization with and without closed renal circuit: pharmacokinetic and histologic assessment in pigs.

有和没有闭合肾回路的经导管肾动脉栓塞的比较研究：猪的药代动力学和组织学评估。

• DOI: 10.1148/radiol.2503080215
• 发表时间: 2009
• 期刊: Radiology
• 影响因子: 19.7
• 作者: S. Onozawa;S. Murata;A. Shimizu;H. Tajima;F. Hidaka;S. Kumita;Kazuhiro Nomura
• 通讯作者: Kazuhiro Nomura

Pharmacological advantages of negative-balance isolated pelvic perfusion : Achievement of intensive exposure of the pelvis to platinum without systemic leakage.

负平衡盆腔隔离灌注的药理学优势：实现骨盆密集暴露于铂而无全身渗漏。

• 发表时间: 2011
• 期刊: Radiology (in press)
• 作者: Murata S;Onozawa S;Oda T.;et al
• 通讯作者: et al

Pharmacological advantages of negative-balance isolated pelvicperfusion : Achievement of intensive exposure of the pelvis to platinum without systemic leakage

负平衡隔离盆腔灌注的药理学优势：实现骨盆密集暴露于铂而无全身渗漏

• 发表时间: 2011
• 期刊: Radiology
• 影响因子: 19.7
• 作者: Murata S;Onozawa S;Oda T;et al.
• 通讯作者: et al.

Retrograde-outflow isolated hepatic perfusion without laparotomy in a pig model

猪模型中无需剖腹手术的逆行离体肝灌注

• 发表时间: 2010
• 作者: Bowsher J;Takai Y;et al;Satoru Murata
• 通讯作者: Satoru Murata