NOVEL DIAGNOSTIC AND THERAPEUTIC STRATEGY FOR AORTIC ANEURYSM

腹主动脉瘤（AAA）是一种由主动脉节段性衰弱和扩张引起的致命性疾病。在本项目中，我们发现tenascin-C （TNC）是一种基质细胞蛋白，在AAA的活动性病变处表达，可能对主动脉组织有保护作用。我们还发现，较高的血清TNC水平与AAA血管内修复后更好的预后相关，这表明血清TNC水平可能是一个有用的生物标志物。

Abdominal aortic aneurysm (AAA) is a fatal disease caused by the segmental weakening and dilation of aorta. In this project we found that tenascin-C (TNC), a matricellular protein, was expressed at the active lesion of AAA and may protect the aortic tissue. We also found that higher level of serum TNC was associated with the better outcome after the endovascular repair of AAA, suggesting that serum TNC level may be an useful biomarker in this context.