Identification of neural induction domain in stem cells and neuronal regenerative medicine using the peptide derived from the domain

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We identified a neural induction domain for somatic stem cells at elonign BC binding site in the VHL protein, and show neuronal differentiation of the cells by transfer of the domain peptide linked to protein transduction domain (PTD). In addition, we show that the domain has the same function for the other somatic stem cells, and that BC-box motifs within SOCS-box proteins also have an ability to induce neuronal differentiation. Furthermore, when the domain peptide-transferred stem cells are grafted into recipient nervous tissue, the grafted cells differentiate to neurons and recovery of the neuronal symptom is recognized. Thus, the neuronal differentiation of pluripotent somatic stem cells is occurred by transfer of the neural induction domain peptide linked to PTD and would contribute to neuronal regenerative therapy.