Isolation of pluriptent somatic stem cells for neuronal regenerative medicine and neuronal differentiation peptide-mediated neuronal differentiation
Isolation of pluriptent somatic stem cells for neuronal regenerative medicine and neuronal differentiation peptide-mediated neuronal differentiation
批准号:
23390353
负责人:
KANNO Hiroshi
金额:
$11.98万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011-04-01 至 2014-03-31
中文摘要
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英文摘要
We used neural stem cells and skin-derived mesenchymal stem cells as pluripotent somatic stem cells to neuronal lineage. Eleven BC-box proteins(SOCS1-7, ASB3, WSB2, LRR1, VHL)-derived functional peptides are delivered to those somatic stem cells. Each peptide induced to differentiate different type of neuron. VHL and socs7-derived peptides induced to differentiate dopaminergic and motor neurons, and SOCS5-derived peptide induced to differentiate retinal color epithelial cells and gultamate neuron. This mechanism of neuronal differentiation is suggested to be related to degeradation of Stat3, but is under investigation.
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Role of the von Hippel-Lindau tumor suppressor protein during neuronal differentiation of somatic stem cells and its application to neuronal regeneration
von Hippel-Lindau抑癌蛋白在成体干细胞神经元分化过程中的作用及其在神经元再生中的应用
DOI:
--
发表时间:
2014
期刊:
J Transl Med Epidemiol
影响因子:
--
作者:
[Kanno H, Kubo A, Higashida T]
通讯作者:
Higashida T
DOI:
10.4252/wjsc.v5.i4.163
发表时间:
2013-10-26
期刊:
World journal of stem cells
影响因子:
4.1
作者:
[Kanno, Hiroshi]
通讯作者:
Kanno, Hiroshi
Role of the von Hippel-Lindau tumor suppressor protein in neuronal differentiation of somatic stem cells and its application to neuronal regeneration: a review
von Hippel-Lindau肿瘤抑制蛋白在成体干细胞神经元分化中的作用及其在神经元再生中的应用:综述
DOI:
--
发表时间:
2014
期刊:
Journal of Translational Medecine & Epidemiology
影响因子:
--
作者:
[Kanno H, Higashida T, Kubo A]
通讯作者:
Kubo A
DOI:
10.3892/ijo.2013.1773
发表时间:
2013-03-01
期刊:
INTERNATIONAL JOURNAL OF ONCOLOGY
影响因子:
5.2
作者:
[Kanno, Hiroshi, Sato, Hidemitsu, Yamada, Sachiko]
通讯作者:
Yamada, Sachiko
VHL regulates tumorigenecity of cancer stem cells through in hibition of Stat3 signaling pathways
VHL 通过抑制 Stat3 信号通路调节癌症干细胞的致瘤性
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Kanno H, Yoshizumi T, Yamada S]
通讯作者:
Yamada S
共 12 条
Mechanism of neruonal differention of pluripotent mesenchymal stem cells by intracullular delivery of BC-box motif peptides
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批准号:24659655
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
-
财政年份:2012
-
负责人:KANNO Hiroshi
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依托单位:
Research on the Buddhist Studies of the Southern Dynasties of China: Based on a Comparison between the Dasheng silun xuanyi ji and the Dasheng xuanlun
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批准号:23520069
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.08万
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财政年份:2011
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负责人:KANNO Hiroshi
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依托单位:
Identification of neural induction domain in stem cells and neuronal regenerative medicine using the peptide derived from the domain
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批准号:20390389
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.23万
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财政年份:2008
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负责人:KANNO Hiroshi
-
依托单位:
Reconstruction of Buddhist Studies in the Southern Dynasties of China Based on Huijun's Dasheng silun xuanyi ji
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批准号:19520055
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.5万
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财政年份:2007
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负责人:KANNO Hiroshi
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依托单位:
Neural induction of somatic stem cells / ES cells by VHL gene /peptide and application to regenerative medicine
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批准号:16390415
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.59万
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财政年份:2004
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负责人:KANNO Hiroshi
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依托单位:
Induction of neuronal differentiation of stem cell or cancer cell with VHL-gene transfer and neuronal regeneration using the transferred cells
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批准号:13557120
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$3.9万
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财政年份:2001
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负责人:KANNO Hiroshi
-
依托单位:
Role of Neuronal differentiation and Regeneration of VHL Tumor Suppressor Gene
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批准号:12671374
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.15万
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财政年份:2000
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负责人:KANNO Hiroshi
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依托单位:
Role of VHL tumor suppressor gene in central nervous system
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批准号:09671435
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.86万
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财政年份:1997
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负责人:KANNO Hiroshi
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依托单位:
Molecular diagnosis of von Hippel-Lindau disease (VHL) using VHL tumor suppressor gene and the research for the VHL gene product
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批准号:06671410
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.22万
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财政年份:1994
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负责人:KANNO Hiroshi
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依托单位:
海外基金