Translational research of animal study and clinical trial for the mechanisms of weather-dependent pain aggravation.
Translational research of animal study and clinical trial for the mechanisms of weather-dependent pain aggravation.
批准号:
20390415
负责人:
SATO Jun
金额:
$12.23万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
The authors have clarified underlying mechanisms of weather-sensitive diseases, such as chronic pain and depression in the basic animal research. In the present research project, we have further progressed the animal study and had clinical study using chronic pain patients with their pain to be sensitive to weather change. This translational study succeeded to product human model of weather-sensitive pain and provided a scientific link between laboratory research and human trials, and the beginning of discovery of therapeutic strategies for this syndrome.
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Increases in neuronal activity in rat spinal trigeminal nucleus following changes in barometric pressure-relevance for weather-associated headache
气压变化导致大鼠三叉神经脊髓神经元活动增加,与天气相关的头痛相关
DOI:
--
发表时间:
2010
期刊:
Headache Vol.50, No.9
影响因子:
--
作者:
[MESSLINGER Karl, FUNAKUBO Megumi, SATO Jun, MIZUMURA Kazue]
通讯作者:
MIZUMURA Kazue
ストレス誘発性抑うつモデルマウスにみられた神経障害性疹痛の増強
应激性抑郁模型小鼠神经病理性疼痛的增强
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kiya T, Kawamarta T, Yamakage M, 大宮康次郎]
通讯作者:
大宮康次郎
気象病における自律神経系の関与
自主神经系统与气象疾病的关系
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[松井博, 他(全8名), 佐藤純]
通讯作者:
佐藤純
Impairments of subjective sensitivity and thermoregulatory function in chronic pain patients exposed to ambient temperature change
暴露于环境温度变化的慢性疼痛患者主观敏感性和体温调节功能受损
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[A. Nakae, K. Nakai, S. Oba, K. Ueda, T. Mashimo, 小笠原邦昭, Kawamata T, Sakurai Hiroki]
通讯作者:
Sakurai Hiroki
Chronic mechanical hyperalgesia and local extravasation induced by two-week cast immobilization in rats
两周石膏固定诱发大鼠慢性机械性痛觉过敏和局部外渗
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[小笠原邦昭, 菅康徳, 千田光平, 小林正和, 吉田研二, 小川彰, Ohmichi Yusuke]
通讯作者:
Ohmichi Yusuke
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External activities of the Bank of England in the inter-war period ; a study on Niemeyer's role in creating and reforming central banks in Australasia
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3D Reconstruction from Ubiquitous Vehicle Cameras
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Recovering 3D Geometry from Mutual Projection of Multiple Cameras
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