Proteomic analysis of ischemic cochlear damage as a diagnostic tool of sudden sensorineural hearing loss

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Pathology of transient cochlear ischemia as a cause of sudden deafness was investigated in gerbils. 1) Proteomic analysis showed that two genes, encoding GPCRs Class A and Peptide GPCRs, were dominantly expressed, suggesting needs for clinical study. 2) Cochlear damage was ameliorated by applying minor ischemia 2 days before major ischemia 3) Administration of AM-111, an apoptosis inhibitor, on the round window membrane was proved effective in decreasing damage of the cochlea.