Liposome-encapsulated hemoglobin alleviates inner eardamage after transient cochlear ischemia in the gerbil

点击翻译按钮获取中文摘要

To test liposome-encapsulated hemoglobin (LEH) in transient cochlear ischemia/reperfusion as a model of sudden deafness, Mongolian gerbils were randomly assigned to receive 2 mL/kg of either low-affinity LEH (l-LEH, P50O2 = 40 mm Hg), high-affinity LEH (h-LEH, P50O2 = 10 mm Hg), homologous red blood cells (RBCs), or saline (each group n = 6) 30 min before 15-min occlusion of the bilateral vertebral arteries and reperfusion. As a result, h-LEH was significantly more protective than l-LEH in suppressing hearing loss, in contrast to RBC or saline treatment. The results suggested that pretreatment with h-LEH is significantly more protective than l-LEH in mitigating hearing loss and underlying pathological damage, in contrast to transfusion or saline infusion.