The development of a new therapeutic moleculefor Japanese cedar pollinosis by proteomics analysis in the serum of patients treated with sublingual immunotherapy

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Seasonal allergic rhinitis caused by Japanese cedar (SAR-JC) is the most common allergic disease in Japan. The results of our recent study showed that about 30% of Japanese individuals develop allergic symptoms during JC pollination season. Allergen-specific immunotherapy (SIT) is the only available treatment that can provide long-term remission after discontinuation of treatment. Sublingual immunotherapy (SLIT), oral administration of the allergen, was introduced as a safety method. We found that apolipoprotein A-IV (apoA-IV) were significantly increased in SLIT-treated patients. The serum levels of apoA-IV correlated with the clinical effect. The amount of histamine released from the basophils in vitro was greatly reduced after the addition of recombinant apoA-IV in the medium. Our genetic studies found the association of polymorphisms of IL-33, DAF and Filaggrin with SAR-JC. They are possible therapeutic targets for SAR-JC.