Demonstration of PACAP on protection of delayed neuronal cell death and its molecular mechanism of neuroregeneration.

点击翻译按钮获取中文摘要

We have studied to clarify the molecular basis for PACAP on protection of delayed neuronal cell death after brain ischemia in mice and to make a translational study for humans. I n addition, we have also studied the molecular mechanism of PACAP on stimulating differentiation from neural stem cells into neurons and/or glial cells. Moreover, we developed a new drug delivery system (DDS) of PACAP by use of intranasal infusion to protect delayed neuronal cell death after brain ischemia. The present study will have a strong impact for protection of brain ischemia and it will open a new avenue to use of PACAP and its related peptides for clinical use for patients who will be suffered from neurodegeneration after brain ischemia with a new developed DDS.