Demonstration of PACAP on protection of delayed neuronal cell death and its molecular mechanism of neuroregeneration.

PACAP对迟发性神经细胞死亡的保护作用及其神经再生的分子机制的论证。

• 批准号: 20390461
• 负责人: SHIODA Seiji
• 金额: $ 12.4万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390461/
• 关键词: PACAP; PAC1-R; IL-6; 神経細胞死; 神経再生; PAC-1R

We have studied to clarify the molecular basis for PACAP on protection of delayed neuronal cell death after brain ischemia in mice and to make a translational study for humans. I n addition, we have also studied the molecular mechanism of PACAP on stimulating differentiation from neural stem cells into neurons and/or glial cells. Moreover, we developed a new drug delivery system (DDS) of PACAP by use of intranasal infusion to protect delayed neuronal cell death after brain ischemia. The present study will have a strong impact for protection of brain ischemia and it will open a new avenue to use of PACAP and its related peptides for clinical use for patients who will be suffered from neurodegeneration after brain ischemia with a new developed DDS.

我们的研究旨在阐明PACAP对小鼠脑缺血后迟发性神经元细胞死亡的保护作用的分子基础，并进行人的转化研究。此外，我们还研究了PACAP促进神经干细胞向神经元和/或胶质细胞分化的分子机制。此外，我们还开发了一种新的PACAP给药系统（DDS），通过鼻内给药来保护脑缺血后迟发性神经细胞死亡。本研究将对脑缺血的保护作用产生重大影响，并将为PACAP及其相关肽用于临床开辟一条新的途径，用于脑缺血后患有神经退行性变的患者。

项目成果

Suppression of Ganglion Cell Death by PACAP Following Optic Nerve Transection in the Rat

• DOI: 10.1007/s12031-008-9091-5
• 发表时间: 2008-07
• 期刊: Journal of Molecular Neuroscience
• 影响因子: 3.1
• 作者: T. Seki;Hiroyuki Itoh;T. Nakamachi;S. Shioda

Changes in the Expression of PACAP-like Coipounds During the Embryonic Development of the Earthworm Eisenia fetida.

蚯蚓胚胎发育过程中 PACAP 样化合物表达的变化。

• 发表时间: 2008
• 期刊: J Mol Neurosci 36
• 作者: Boros A;et al.
• 通讯作者: et al.

Endogenous PACAP protects the brain against focal cerebral ischemia in mice (Symposium).

内源性 PACAP 可保护小鼠大脑免受局灶性脑缺血（研讨会）。

• 发表时间: 2009
• 作者: Nakamachi T;Ohtaki H;Nonaka N;Banks WA;Shioda S;他1名
• 通讯作者: 他1名

Effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on the survival of ganglion cells in the rat retina after intraocular hypertension.

垂体腺苷酸环化酶激活多肽（PACAP）对高眼压后大鼠视网膜神经节细胞存活的影响。

• 发表时间: 2009
• 作者: Itoh H;Seki T;Nakamachi T;Endo K;Shioda S
• 通讯作者: Shioda S

Endogenous PACAP attenuated doxorubicin-induced myocardial damage.

内源性 PACAP 可减轻阿霉素诱导的心肌损伤。

• 发表时间: 2009
• 作者: Mori H;Nakamachi T;Ohtaki H;Hasegawa F;Yofu S;Suzuki H;Takeyama Y;Shintani N;Hashimoto H;Baba A;Shioda S
• 通讯作者: Shioda S