Alveolar bone phenotype and their aging changes identified by collagen biochemical analysis

骨质疏松症是指骨量和骨质的减少。在这种疾病中，作为骨骼质量决定因素的胶原蛋白在数量和质量上都有所下降，甚至在下颌骨也是如此。在未发生骨质疏松的下颌骨中，胶原的数量和质量存在个体差异，但不依赖于骨量和年龄。下颌骨的骨量在个体间存在差异，但不受年龄的影响，女性皮质骨中的骨量与年龄无关。下颌骨中的胶原生化状态与骨量的相关性较小，而与骨质量密切相关。

Osteoporosis shows the decrease of bone quantity and quality. In this disease, collagen, a determinant of bone quality, declines quantitatively and qualitatively, so did even in the mandible. In the mandibles which did not have osteoporotic condition, collagen quantity and quality exhibited inter-individual variation but not dependence on bone quantity and aging. Bone quantity of the mandible exhibited variation among individuals, but did not depend on aging except for in the cortical bone in females. Collagen biochemical conditions in the mandible appear to be less related with the bone quantity, rather be closely related with the bone quality.