Titanium implant surface modification and tissue regeneration by phosphorylated pullulan

研究了牙种植体治疗中骨诱导活性的提高和新开发的用于上部结构（冠、桥等）的粘合剂。植入术后2周，磷酸化普鲁兰多糖处理的钛表面新骨形成明显增强。含15-20%氨基酸（胱氨酸）的氨基甲酸酯二甲基丙烯酸酯聚合物的Ag-Au-Pt-Cu合金的骨强度为22.4MPa（SD：1.8），在5-55℃下热循环20.000次后，骨强度仅下降10%。

The improvement of bone formation-inducing activity for dental implant treatment and the newly developed adhesive for superstructure (crown, bridge, etc) were investigated. At 2 weeks after the implant surgery in rat tibia, the enhanced new bone formation was showed on the titanium surface treated with phosphorylated pullulan. The bone strength to Ag-Au-Pt-Cu alloys of 15-20% derivatized amino acid (cystine) containing urethane dimethacrylate polymers was 22.4MPa(SD:1.8),and the degradation of the bone strength was only 10% after thermal cycling with 20.000 cycles at 5-55℃.