Hybrid formation and improvement for bonding to tooth hard tissue

基于粘附性表面处理和功能性大分子的粘合剂的改进允许在从龋齿预防到修复修复的广泛领域中使用粘合牙科技术。然而，在严重的口腔内条件下的粘附在边缘密封、粘附强度和耐久性方面存在问题。其主要原因可能是牙体结构与粘接剂（树脂）之间界面层的形成、结构和力学性能。为了获得良好的界面层形成，在这项研究中，我们开发和分析了一种底漆的性能与界面层的结构元素，这是磷灰石和胶原蛋白之间的强相互作用。1）底漆是通过合成氨基酸甲基丙烯酸酯（NMGGly，NMBu，NAAsp，NMVa，NMCa等）和溶解在蒸馏水中的一系列浓度制备的。2)通过测量获得引物与牙本质胶原的相互作用 ...更多信息 3）对于粘结强度测量，用实验底漆处理用碳化硅纸（600-粒度）研磨的人和牛牙本质，然后施加市售的酯-磷酸盐基粘结剂并用复合树脂填充。4)用扫描电镜和透射电镜对粘接界面和粘接表面进行了结构分析，胶原蛋白与基于氨基酸甲基丙烯酸酯溶液的底漆之间的相互作用因氨基酸的类型而异。强组合的顺序为：Va>Bu>Ca>Ala>Gly。用40%磷酸处理牙本质后，粘接剂与各种底漆的粘接强度为9 ~ 16 MPa，与胶原和底漆的相互作用结果相关。在粘接界面的牙本质侧形成4 ~ 6 μm宽的胶原与聚合树脂的混合层。这项研究的结果表明，底漆与粘附基板的强相互作用是必不可少的粘附。少

Improvements in adhesives based on adherent surface treatment and functional macromolecules have permitted the use of adhesive dentistry technique in a wide field, from caries prevention through prosthetic rehabilitation. However, the adhesion within the severe intra-oral conditions presents problems in marginal sealing, adhesive strength and durability. The main reasons may be the formation, structure and mechanical properties of the interfacial layer between the tooth structure and the adhesive (resin). Aiming to obtain a sound interfacial layer formation, in this study we developed and analyzed the properties of a primer with strong interaction between the structural elements of the interfacial layer, which are apatite and collagen.1) The primer was prepared by synthesis of aminoacid methacrylates (NMGly, NMBu, NAAsp, NMVa, NMCa, etc) and dissolution in distilled water in a series of concentrations. 2) The interaction between primer and dentinal collagen was obtained by measurement … More of the relaxation time (T1) with NMR.3) For bond strength measurements, human and bovine dentin ground with silicon carbide paper (600-grit) were treated with the experimental primers, followed by application of a commercially available ester-phosphate based bonding agent and filling with composite resin. 4) The SEM and TEM were used for structural analysis of the adhesive interfaces and adherent surfaces.The interaction between collagen and primers based on amino-acid methacrylate solutions varied depending on the type of aminoacid. The sequence of strong combinations was as follows : Va>Bu>Ca>Ala>Gly. The bond strength of bonding agents after treatment to dentin with 40% phosphoric acid and each type of primer was from 9 to 16 Mpa, showing correlation with the results for collagen and primer interactions. A hybrid layer of collagen and polymerized resin 4 to 6 μm wide was formed in the dentin side of the adhesive interface. The results of this study show that a primer with strong interaction to the adherent substrate is indispensable for adhesion. Less