Molecular basis of predictable periodontal regeneration

fgf -2诱导的beagle模型牙周再生转录组分析显示，PLXNC1、SMOC1、SMOC2、TNS3、NPNT、SPON1、WDHD1等多个基因在间充质干细胞成骨分化中发挥重要作用。此外，还发现了牙周膜特异性剪接异构体。另一方面，牙周膜特异性分子PLAP-1具有天冬酰胺酸重复多态性。重要的是，这些分子差异影响了它们调节牙周韧带细胞分化的能力。这些结果表明，这些基因可能在预测牙周组织再生治疗的结果中起重要作用。

Transcriptome analysis of FGF-2-induced periodontal regeneration in beagle model revealed that several genes (PLXNC1, SMOC1, SMOC2, TNS3, NPNT, SPON1, WDHD1, etc.) can play important roles in osteogenic differentiation of mesenchymal stem cells. In addition, periodontal ligament specific splicing isoform of Periostin was found. On the other hand, PLAP-1, periodontal ligament specific molecule, has an asparagine acid repeat polymorphism. Importantly, these molecular differences affected their abilities to regulate differentiation of periodontal ligament cells. These results suggest that these genes may play important roles in predicting outcomes of regenerative therapy for periodontal tissue.