Molecular patho-epidemiological study on oral superficial carcinoma in East Asia regions

口腔癌，特别是浅表癌，不仅在日本，而且在亚洲国家也在增加，这似乎与这些国家进入老龄化社会的变化是同步的。通过对日本和东亚病例的流行病学和分子病理学比较，我们建立了原位癌的病理诊断标准，证明口腔浅表癌是一种由上皮异常增生到微侵袭性癌的交界性恶性肿瘤的病变复合物，具有生物学证据。

Oral cancers, especially superficial carcinomas, are increasing in number not only in Japan but also Asian countries, which seems to be in parallel to changing of those countries into aging societies. Epidemiologically and molecular pathologically comparing Japanese cases and East Asian cases, we have shown that oral superficial carcinoma is a lesional complex of borderline malignancies including from epithelial dysplasia to micro-invasive carcinoma by establishing pathological diagnostic criteria for carcinoma in-situ, which were biological evidence-based.