Molecular neurobiological studies on the functions of α-Synuclein
Molecular neurobiological studies on the functions of α-Synuclein
批准号:
20500303
负责人:
UEDA Kenji
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
After the biochemical examination of SDS-insoluble materials of the brains with Alzheimer's disease, we identified human α-Synuclein by cDNA cloning. Later, some missense mutations of the gene of α-Synuclein were found in the cases with familial Parkinson's disease. α-Synuclein turned out to be the major component of Lewy bodies. In the present studies, we identified that α-Synuclein is localized in the inner membrane of neuronal mitochondria.
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Mitochondrial α-synuclein : Implications in neurodegenerative diseases
线粒体 α-突触核蛋白:对神经退行性疾病的影响
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Ueda K, Yu S, et al]
通讯作者:
et al
The biology and pathology of α-synuclein, Symposium "α-Synuclein in Neurodegenerative Disease"
α-突触核蛋白的生物学和病理学,研讨会“神经退行性疾病中的α-突触核蛋白”
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Fujiwara MT, 他, Jung CG., Ueda K]
通讯作者:
Ueda K
Analysis of contribution of dopamine of oligomeric intermediate in initial stage of α-Synuclein amyloidogenesis and the structural feature.
寡聚中间体多巴胺在α-Synuclein淀粉样变起始阶段的贡献及结构特征分析。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Shiroyama Y, Ueda K, et al. Shimotakahara S]
通讯作者:
et al. Shimotakahara S
Melatonin decreases α-synuclein in mesolimbic pathway of amphetamine-treated postnatal rats.
褪黑激素降低安非他明治疗的产后大鼠中脑边缘通路中的 α-突触核蛋白。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Sae-ung K, Govitrapong P, Ueda K, Phansuwan-Pujito P]
通讯作者:
Phansuwan-Pujito P
Immunocytochemical study of methamphetamine induced α-synuclein in SK-N-SH cells
SK-N-SH 细胞中甲基苯丙胺诱导的 α-突触核蛋白的免疫细胞化学研究
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Boontem P, Phansuwan-Pujito P, Ueda K, Govitrapong P]
通讯作者:
Govitrapong P
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Uncovering the soil microbial community structure based on humus-metaboilzing activity of actinomycetes
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Fabrication of novel spintronic devices using the ferromagnet/diamond semiconductor heterostructures
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Connection between respiration and secondary metabolite formation in Streptomyces : An unknown role of the terminal respiratory enzymes
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Study on the glucose repression mechanism for the initiation of morphological differentiation and secondary metabolism in Streptomyces
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依托单位:
The control of morphological differentiation and secondary metabolism by AmfS autoregulatory peptide in Streptomyces
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依托单位:
Molecular pathophysiology of α-Synuclein : Molecular mechanisms of neurodegenerative diseases
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Mechanisms of neurodegeneration with NACP/α-synuclein, a causal gene of Parkinson's disease
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依托单位:
Physiological role of NACP,the precursor of non-Abeta component of Alzheimer's disease amyloid
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依托单位:
海外基金