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Molecular neurobiological studies on the functions of α-Synuclein

Molecular neurobiological studies on the functions of α-Synuclein
α-突触核蛋白功能的分子神经生物学研究
批准号:
20500303
负责人:
UEDA Kenji
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
After the biochemical examination of SDS-insoluble materials of the brains with Alzheimer's disease, we identified human α-Synuclein by cDNA cloning. Later, some missense mutations of the gene of α-Synuclein were found in the cases with familial Parkinson's disease. α-Synuclein turned out to be the major component of Lewy bodies. In the present studies, we identified that α-Synuclein is localized in the inner membrane of neuronal mitochondria.
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Mitochondrial α-synuclein : Implications in neurodegenerative diseases
线粒体 α-突触核蛋白:对神经退行性疾病的影响
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Ueda K, Yu S, et al]
通讯作者: et al
The biology and pathology of α-synuclein, Symposium "α-Synuclein in Neurodegenerative Disease"
α-突触核蛋白的生物学和病理学,研讨会“神经退行性疾病中的α-突触核蛋白”
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Fujiwara MT, 他, Jung CG., Ueda K]
通讯作者: Ueda K
Analysis of contribution of dopamine of oligomeric intermediate in initial stage of α-Synuclein amyloidogenesis and the structural feature.
寡聚中间体多巴胺在α-Synuclein淀粉样变起始阶段的贡献及结构特征分析。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Shiroyama Y, Ueda K, et al. Shimotakahara S]
通讯作者: et al. Shimotakahara S
Melatonin decreases α-synuclein in mesolimbic pathway of amphetamine-treated postnatal rats.
褪黑激素降低安非他明治疗的产后大鼠中脑边缘通路中的 α-突触核蛋白。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Sae-ung K, Govitrapong P, Ueda K, Phansuwan-Pujito P]
通讯作者: Phansuwan-Pujito P
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