Connection between respiration and secondary metabolite formation in Streptomyces : An unknown role of the terminal respiratory enzymes

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We studied the connection between energy metabolism and secondary metabolism in Streptomyces, the bacteria renowned for the ability to produce useful biologically active substances such as antibiotics. By focusing on the role of enzymes involved in respiration, i. e. the important process at the terminus of energy metabolic flow, we revealed that the major respiratory enzyme termed cytochrome oxidase plays an important role in the signaling for the initiation of antibiotic production. The findings will be fundamental to the development of effective fermentation process for useful substances.