Establishment of a new method to induce differentiation from human ES cells into neural stem cells and neurons

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We have developed a new method to induce uni-directional differentiation from human ES cells into neural cells and to prepare a large amount of homogeneous neural stem cells. The neural stem cells could be selectively induced to differentiate into neurons, mainly dopaminergic neurons, or astrocytes. We have also opened the possibility that human ES cells can be differentiated into many different types of neural cells by simply modifying the basic culture conditions of the method.