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A study on the influences of regional tissue blood flow volume on energy metabolism in deep and superficial part of masseter muscles

局部组织血流量对咬肌深浅部能量代谢影响的研究

基本信息

批准号：
11671970
负责人：
INOUE Nobuo
金额：
$ 2.3万
依托单位：
HOKKAIDO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671970/
关键词：
blood flow volume masticatory muscles energy metabolism 31P-MRS

项目摘要

The purpose of this study was to clarify the the influences of regional tissue blood flow volume (RTVF volume) on energy metabolism in deep and superficial part of masseter muscle (Mm)1. Establishment of 31P-Chemical Shift Imaging (CSI) for human Mm.We have succeeded in analyzing energy metabolism in both deep and superficial part of Mm. It has become clear that the superficial part of Mm contains more phosphocreatine (PCr) than deep part. This result suggests that deep and superficial part of Mm need to be measured separately in analyzing energy metabolism.2. Establishment of analyzing methods of RTVF volume.A three wavelength spectrophotometric method were used. As the parameters of RTVF volume, total hemoglobin (Hb) volume, and ratio and period of change in Hb were selected. It was demonstrated that RTVF volume in Mm changes as head and/or upper half of body lean, and that we need to keep head and body position stable.3. Establishment of condition for exercise task.Among several condition for exercise task such as maximal clenching, gum chewing and so on, 10 kgf clenching for 20 sec. was considered to be adequate.4. Measurements in healthy people and patients with temporomandibular disorders (TMD).As for the energy metabolism, PCr in Mm of TMD patients was lower than that of healthy people. In other words, it was suggested that energy level of Mm in TMD patients was lower than that of healthy people. However, we could not obtain obvious conclusion concerning RTVF volume because of wide variation of the data. Therefore, to diminish the influence of the wide variation and to confirm the relation between energy metabolism and RTVF volume, we need to gather more data in further studies by using the analyzing methods established in this study.

本研究的目的是阐明局部组织血流量(RTVF)对咬肌深浅部能量代谢的影响。1.建立人咬肌深部和浅部的31P-化学位移成像(CSI)，成功地分析了咬肌深部和浅部的能量代谢。很明显，MM的浅层比深层含有更多的磷酸肌酸(Pcr)。这一结果提示，在分析能量代谢时，应分别测量中脑深部和浅部。RTVF体积分析方法的建立：采用三波长分光光度法。选择RTVF体积、总血红蛋白(Hb)体积、Hb变化率和周期作为参数。结果表明，RTVF以mm为单位的体积随着头部和/或上半身的倾斜而变化，需要保持头部和身体位置的稳定。运动任务条件的建立：在最大咬合、咀嚼口香糖等几种运动任务条件中，10KGF紧握20s。被认为是足够的。颞颌关节紊乱病(TMD)患者能量代谢的检测：TMD患者Mm的PCR值低于健康人。也就是说，TMD患者的MM能量水平低于健康人。然而，由于数据的差异很大，我们无法得到关于RTVF体积的明显结论。因此，为了减少大范围变异的影响，并确定能量代谢与RTVF容量之间的关系，我们需要在进一步的研究中收集更多的数据，使用本研究建立的分析方法。