Functional analysis of muscle regeneration using gene-targeting and transgenic technologies

使用基因靶向和转基因技术进行肌肉再生的功能分析

• 批准号: 20500367
• 负责人: HANAOKA Kazunori
• 金额: $ 3万
• 依托单位: Kitasato University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20500367/
• 关键词: 筋再生; サテライト細胞; Lbx1; Notch3; マウス; Dp71; 筋肉; 幹細胞; 筋ジストロフィー

The results of present study demonstrate Notch3 as an important regulator for muscle repair. The data indicate Notch3 negatively regulate both proliferation and self-renewal of activated satellite cells after muscle injury. These results provide insight into the mechanisms of self-renewal and homeostatic regulation of satellite cells during muscle regeneration.

本研究的结果表明Notch3是肌肉修复的重要调节因子。数据表明，Notch3 对肌肉损伤后激活的卫星细胞的增殖和自我更新负向调节。这些结果提供了对肌肉再生过程中卫星细胞自我更新和稳态调节机制的深入了解。

项目成果

Spatially and temporally regulated expression of specific heparan sulfate epitopes in the developing mouse olfactory system

发育中的小鼠嗅觉系统中特定硫酸乙酰肝素表位的空间和时间调节表达

• 发表时间: 2010
• 期刊: Dev Growth Diff
• 作者: Takatoh J;Hanaoka K
• 通讯作者: Hanaoka K

Specific expressions of mouse denovo methyltransferases during stem cell differentiation

干细胞分化过程中小鼠从头甲基转移酶的特异性表达

• 发表时间: 2009
• 作者: 梅原芳惠;坂本祐基;花岡和則;渡邉大介
• 通讯作者: 渡邉大介

Skeletogenesis in Xenopus tropicalis: Characteristic bone development in an anuran amphibian

• DOI: 10.1016/j.bone.2008.07.005
• 发表时间: 2008-11-01
• 期刊: BONE
• 影响因子: 4.1
• 作者: Miura, Shinichirou;Hanaoka, Kazunori;Togashi, Shin
• 通讯作者: Togashi, Shin

Spatially and temporally regulated expression of specific heparan sulfate epitopes the developing mouse olfactory system

发育中的小鼠嗅觉系统中特定硫酸乙酰肝素表位的空间和时间调节表达

• 发表时间: 2010
• 期刊: Dev Growth Diff 52
• 作者: Takatoh J;Hanaoka K
• 通讯作者: Hanaoka K

Notch3 regulates satellite cell proliferation in adult skeletal muscle

Notch3 调节成人骨骼肌卫星细胞增殖

• 发表时间: 2009
• 作者: 北本武郎;花岡和則
• 通讯作者: 花岡和則