Elucidation of the Frank-Starling mechanism of the heart by thin filament reconstitution

通过细丝重建阐明心脏的 Frank-Starling 机制

• 批准号: 20500368
• 负责人: FUKUDA Norio
• 金额: $ 2.91万
• 依托单位: Jikei University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20500368/
• 关键词: 生理学; 生物物理; 細胞・組織; 生物・生体工学; 生体分子

Cardiac sarcomeres produce greater active force in response to stretch, forming the basis of the Frank-Starling mechanism of the heart. The purpose of this study was to provide the systematic understanding of length-dependent activation, by investigating experimentally and mathematically how the thin filament "on-off" switching mechanism is involved in the regulation. Our experimental analyses revealed that the magnitude of length-dependent activation was inversely correlated with thin filament cooperative activation. These results were quantitatively simulated by a model that incorporates the Ca^<2+>-dependent "on-off" switching of the thin filament state and interfilament lattice spacing modulation. These findings demonstrate that the Frank-Starling relation is regulated by thin filament cooperative activation.

心脏肉瘤在响应拉伸方面产生更大的活性力，这形成了心脏坦率的坦率机制的基础。这项研究的目的是通过通过实验和数学研究如何参与调节的薄丝“开关”开关机制来提供对长度依赖性激活的系统理解。我们的实验分析表明，长度依赖性激活的大小与细丝合作激活成反比。这些结果是通过结合薄丝丝状状态和Interfile晶格间距调制的CA^<2+>的模型进行定量模拟的。这些发现表明，坦率的停滞关系受到细丝合作激活的调节。

项目成果

Microscopic analyses of sarcomeric oscillations in rat neonatal cardiomyocytes.

大鼠新生心肌细胞肌节振荡的显微镜分析。

• 发表时间: 2011
• 作者: S.Shintani;M.Yamane;K.Oyama;S.Kurihara;S.Ishiwata;N.Fukuda
• 通讯作者: N.Fukuda

幼弱心筋細胞における筋収縮自励振動現象(SPOC)の顕微解析

年轻心肌细胞肌肉收缩自激振荡（SPOC）的显微分析

• 发表时间: 2010
• 作者: 新谷正嶺;山根光智;大山廣太郎;栗原敏;石渡信一;福田紀男
• 通讯作者: 福田紀男

Physiological functions of the giant elastic protein titin in mammalian striated muscle

• DOI: 10.2170/physiolsci.rv005408
• 发表时间: 2008-06-01
• 期刊: JOURNAL OF PHYSIOLOGICAL SCIENCES
• 影响因子: 2.3
• 作者: Fukuda, Norio;Granzier, Henk L.;Kurihara, Satoshi
• 通讯作者: Kurihara, Satoshi

筋収縮自励振動現象(SPOC)の生理的意義

肌肉收缩自激振荡现象（SPOC）的生理意义

• 发表时间: 2010
• 作者: 福田紀男;照井貴子;小比類巻生;芹澤隆博;下澤東吾;石渡信一;栗原敏
• 通讯作者: 栗原敏

Nonlinear properties of cardiac sarcomeres : novel insights into the physiology of the heart

心脏肌节的非线性特性：对心脏生理学的新见解

• 发表时间: 2009
• 作者: T.Terui;S.Shingani;S.Ishiwata;S.Kurihara;N.Fukuda;塩見雅志;N.Fukuda
• 通讯作者: N.Fukuda