Development and Assessment of tomosynthesis reconstruction algorithm based on refraction contrast

基于折射衬度的断层合成重建算法的开发与评估

• 批准号: 20500385
• 负责人: YUASA Tetsuya
• 金额: $ 2.91万
• 依托单位: Yamagata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20500385/
• 关键词: 放射光X線; 屈折コントラスト; トモシンセシス; 乳がん; 早期診断; 屈折コントラス

A novel tomosynthesis imaging system for soft tissues using Laue-case analyzer is described. Since the imaging system obtains angular deviation by refraction from the projections simultaneously acquired in forwardly diffracted and diffracted directions, the measurement time as well as the radiation dose required decreases by one half compared to the conventional diffraction enhanced imaging (DEI) method. In addition, the proposed reconstruction algorithm derived from the quantitative relationship in measurement process produces images in no way inferior to refraction-contrast CT images from the viewpoint of morphological imaging in spite of one tenth the radiation dose of refraction-contrast CT imaging. We ex vivo imaged a lung tissue sample excised from a human using the system constructed at the vertical wiggler beamline PF-BL14C in KEK to demonstrate the efficacy of the proposed imaging protocol.

介绍了一种基于劳-格分析仪的软组织断层合成成像系统。由于该成像系统通过对前衍射和衍射方向同时获得的投影进行折射获得角偏差，因此与传统的衍射增强成像（DEI）方法相比，测量时间和所需的辐射剂量减少了一半。此外，本文提出的基于测量过程中定量关系的重建算法，尽管辐射剂量仅为折射对比CT成像的十分之一，但从形态学成像的角度来看，所生成的图像丝毫不逊色于折射对比CT图像。我们使用KEK中垂直摆动波束线PF-BL14C构建的系统对从人体切除的肺组织样本进行离体成像，以证明所提出的成像方案的有效性。

项目成果

X-ray phase-contrast microtomography for visualizing renal microstructures ohamsters

X 射线相差显微断层扫描用于可视化肾脏微观结构

• 发表时间: 2009
• 期刊: Kidney International 75
• 作者: J. Wu;T. Takeda;Thet-Thet-Lwin;A. Momose;N. Sunaguchi;T. Fukami;T. Yuasa;T. Akatsuka
• 通讯作者: T. Akatsuka

Visualization of age-dependent cardiomyopathic model hamster obtained by flu orescent X-ray computed tomography using 1127-IMP

使用 1127-IMP 通过荧光 X 射线计算机断层扫描获得的年龄依赖性心肌病模型仓鼠的可视化

• 发表时间: 2008
• 期刊: Journal of Synchrotron Radiation 15
• 作者: Thet-The-Lwin;T. Takeda;J. Wu;Q. Huo;T. Yuasa;K. Hyodo;and T. Akatsuka
• 通讯作者: and T. Akatsuka

Reconstruction Algorithm of Refraction-Based Computed Tomography from Viewpoint of X-Ray Optics

X射线光学角度的折射计算机断层扫描重建算法

• 发表时间: 2011
• 作者: 和田真一;大久保真樹;舟木歩;村尾晃平;松本徹;曽根脩輔;T. Yuasa.
• 通讯作者: T. Yuasa.

Synchrotron-induced X-ray fluorescence from rat bone and lumber vertebra of different age groups

不同年龄组大鼠骨和腰椎同步加速器诱导的X射线荧光

• 发表时间: 2009
• 期刊: Nuclear Instruments and Methods in Physics Research B Vol.267, Iss.3
• 作者: D.V.Rao;M.Swapna;R.Cesareo;A.Brunetti;T.Akatsuka;T.Yuasa;T.Takeda;G.Tromba;G.E.Gigante
• 通讯作者: G.E.Gigante

Sheet-beam geometry for in vivo fluorescent x-ray computed tomography: proof-of-concept experiment in molecular imaging

• DOI: 10.1364/ol.33.002494
• 发表时间: 2008-11-01
• 期刊: OPTICS LETTERS
• 影响因子: 3.6
• 作者: Huo, Qingkai;Yuasa, Tetsuya;Dilmanian, F. Avraham
• 通讯作者: Dilmanian, F. Avraham