Development and Assessment of tomosynthesis reconstruction algorithm based on refraction contrast

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A novel tomosynthesis imaging system for soft tissues using Laue-case analyzer is described. Since the imaging system obtains angular deviation by refraction from the projections simultaneously acquired in forwardly diffracted and diffracted directions, the measurement time as well as the radiation dose required decreases by one half compared to the conventional diffraction enhanced imaging (DEI) method. In addition, the proposed reconstruction algorithm derived from the quantitative relationship in measurement process produces images in no way inferior to refraction-contrast CT images from the viewpoint of morphological imaging in spite of one tenth the radiation dose of refraction-contrast CT imaging. We ex vivo imaged a lung tissue sample excised from a human using the system constructed at the vertical wiggler beamline PF-BL14C in KEK to demonstrate the efficacy of the proposed imaging protocol.