Development of low-radiation-dose retraction-contrast x-ray computed tomography for breast cancer diagnosis

提出了一种新的基于相位衬度的X射线CT成像方法，该方法采用由硅单晶薄板组成的劳厄分析器和位于分析器下游的两个CCD摄像机。此外，我们还设计了一种数据处理算法来提取折射角偏离入射光束方向的情况，并设计了一种三维CT重建算法来从折射角偏离的投影中重建样品中的折射率分布。我们从理论、仿真和实验的角度证明了该方法的有效性。我们清楚地描绘了TDLU（终末导管小叶单位）在病理样本中的分辨率为10微米。

We proposed a novel x-ray CT imaging method based on phase contrast, which employs a Laue-case analyzer composed of Si single-crystal thin plate and two CCD cameras positioned downstream of the analyzer. In addition, we devised a data processing algorithm to extract refraction angle deviation from the incident beam direction, and a 3 dimensional CT reconstruction algorithm to reconstruct the refraction index distribution in a sample from the projections of refraction angle deviation. We demonstrated the effectiveness from the viewpoints of theory, simulation, and experiment. We clearly delineated TDLU (Terminal Duct Lobular Unit) in a pathological sample at a resolution of 10 microns.