Sonodynamic cancer therapy-the combination effects of an anticancer drug and a sonosensitizer

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Low-intensity ultrasound irradiation with a sonosensitizer (sonodynamic therapy, SDT) is one of the promising candidates for cancer therapy because of the deeper tissue penetrating ability than light and lower phototoxicity than photodynamic therapy with a photosensitizer. In order to develop SDT, DEG, a novel sonosensitizer, was characterized and assessed. Furthermore, Combinational effect of an anticancer drug and DEG on SDT was evaluated both in vitro and in vivo. The synergistic antitumor effect was observed in mouse xenograft model as well as in vitro cytotoxic assay in combination of DEG and anticancer drug on ultrasound irradiation, suggesting that the SDT in combination of DEG and anticancer drug might be a useful treatment for cancer.