Construction of a metastatic model in cancer for searching the metastatic inhibitor

本项目旨在建立一种新的肿瘤转移模型，寻找通过阻止肿瘤细胞与靶器官相互作用而起作用的抗转移药物。该模型使用shRNA生成的HLC-1细胞表面CEACAM6含量较低的HLC-1细胞，观察到与细胞外基质胶原IV相互作用的细胞数量减少，这意味着该模型系统可能是寻找新型转移抑制剂的有用工具。

The aim of this project is to make a novel metastatic model in cancer for searching the anti-metastatic agent, that works by preventing the interaction between tumor cells and the target organ. The reduction of cell number interacting with collagen IV, an extracellular matrix, was observed in this model using HLC-1 cells with less amount of CEACAM6 on the cellular surface generated by shRNA, meanings that this model system might be a useful tool for searching a novel metastatic inhibitor.