Construction of a metastatic model in cancer for searching the metastatic inhibitor

本项目的目的是建立一种新的肿瘤转移模型，通过阻止肿瘤细胞与靶器官之间的相互作用来寻找抗转移药物。在该模型中，使用由shRNA产生的较少CEACAM6的HLC-1细胞，观察到与细胞外基质IV型胶原相互作用的细胞数量减少，这意味着该模型系统可能是寻找新的转移抑制因子的有用工具。

The aim of this project is to make a novel metastatic model in cancer for searching the anti-metastatic agent, that works by preventing the interaction between tumor cells and the target organ. The reduction of cell number interacting with collagen IV, an extracellular matrix, was observed in this model using HLC-1 cells with less amount of CEACAM6 on the cellular surface generated by shRNA, meanings that this model system might be a useful tool for searching a novel metastatic inhibitor.