Construction of a metastatic model in cancer for searching the metastatic inhibitor

构建癌症转移模型以寻找转移抑制剂

• 批准号: 23650628
• 负责人: SHIBAGUCHI Hirotomo
• 金额: $ 2.58万
• 依托单位: Fukuoka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23650628/
• 关键词: 抗がん物質検索・ケミカルバイオロジー; がん転移モデル; がん転移; anoikis; 細胞外マトリクス; CEACAMファミリー; 抗体

The aim of this project is to make a novel metastatic model in cancer for searching the anti-metastatic agent, that works by preventing the interaction between tumor cells and the target organ. The reduction of cell number interacting with collagen IV, an extracellular matrix, was observed in this model using HLC-1 cells with less amount of CEACAM6 on the cellular surface generated by shRNA, meanings that this model system might be a useful tool for searching a novel metastatic inhibitor.

本项目的目的是建立一种新的肿瘤转移模型，通过阻止肿瘤细胞与靶器官之间的相互作用来寻找抗转移药物。在该模型中，使用由shRNA产生的较少CEACAM6的HLC-1细胞，观察到与细胞外基质IV型胶原相互作用的细胞数量减少，这意味着该模型系统可能是寻找新的转移抑制因子的有用工具。

项目成果

Sonodynamic cancer therapy: a non-invasive and repeatable approach using low-intensity ultrasound with a sonosensitizer.

• 发表时间: 2011-07
• 期刊: Anticancer research
• 影响因子: 2
• 作者: H. Shibaguchi;H. Tsuru;M. Kuroki;M. Kuroki

超音波のがん治療への応用

超声波在癌症治疗中的应用

• 发表时间: 2011
• 期刊: Research
• 影响因子: 11
• 作者: 芝口浩智;他
• 通讯作者: 他

Sonodynamic cancer therapy using low-intensity ultrasound with novel porphyrin derivatives

使用低强度超声和新型卟啉衍生物进行声动力癌症治疗

• 发表时间: 2011
• 期刊: Proceedings of the 20^<th> annual meeting of the Japan society of sonochemistry and the international workshop on advanced sonochemistry
• 作者: Shibaguchi H;Tsuru H;Hachimine K;Kuroki M;Kuroki M.
• 通讯作者: Kuroki M.