Determination of optimal thermotherapy and study of the mechanisms underlying the effect of heat shock in cultured cells

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The aim of this study was to elucidate the cellular mechanisms underlying the therapeutic effects of heat. To that end, we studied the optimal heat conditions for enhancement of pressed silk-mediated 3D-like proliferation of normal human dermal fibroblasts as well as the responses to heat shock of cells and intracellular signaling pathways. We observed changes in the 3D-like proliferation pattern induced by heat treatment at 43℃ for 10 min and found that activation of p38 MAPK and Hsp27 by the same heat treatment is associated with 3D-like cell proliferation.