Effects of prolyl hydroxylase inhibitor treatment on oxygen sensing mechanism in skeletal muscles

最近，一个家族的O2依赖性脯氨酰羟化酶结构域的酶已被确定为细胞的氧传感机制。脯氨酰羟化酶活性降低促进缺氧诱导因子（HIF-1 α）的积累。本研究旨在探讨补充脯氨酰羟化酶抑制剂对肌肉氧感受机制的影响。目前的研究结果表明，脯氨酰羟化酶抑制剂促进毛细血管生成和糖酵解酶活性通过HIF-1 α上调后腿肌肉。

Recently a family of O2-dependent prolyl hydroxylase domain-containing enzymes has been identified as a cellular oxygen sensing mechanism. Reduced prolyl hydroxylase activity facilitates an accumulation of hypoxia-inducible factor (HIF-1alpha). This study was designed to examine the effects of prolyl hydroxylase inhibitor, supplementation on muscle oxygen sensing mechanism. The present results suggest that prolyl hydroxylase inhibitor facilitates capillary angiogenesis and glycolytic enzyme activity via HIF-1alpha upregulation in hind-leg muscles.