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The relation between effect of passive smoking on immune system in the lung and lung carcinogenesis

The relation between effect of passive smoking on immune system in the lung and lung carcinogenesis
被动吸烟对肺部免疫系统的影响与肺癌发生的关系
批准号:
20500606
负责人:
TAKEUCHI Minoru
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

项目摘要

项目成果

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中文摘要
翻译
侧流烟草烟雾(STS)增加AM数量和ROS产生抑制巨噬细胞吞噬功能、肿瘤坏死因子-α基因表达和TLR。STS对AM细胞DNA的损伤作用STS是AM DNA损伤的危险因素,通过DNA损伤抑制AM的免疫功能。STS对AM免疫功能的抑制可能与肺癌的发生有关。
英文摘要
Side-stream tobacco smoke(STS) increased the number and ROS productions of AM. Phagocytic activity, expressions of TNF-αmRNA and TLRs were inhibited by STS. STS induced DNA damage in AM. STS was a risk factor for DNA damage of AM and inhibited the immunological functions in AM mediated by DNA damage. The inhibition of immunological functions in AM by STS may be associated with carcinogenesis in the lung.
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会议论文
タバコ主流煙による肺胞マクロファージのDNA損傷の誘導とアポトーシスの制御
主流香烟烟雾诱导肺泡巨噬细胞DNA损伤并调节细胞凋亡
DOI: --
发表时间: 2010
期刊: 京都産業大学論集、自然科学系列 第39号
影响因子: --
作者: [廣野由里子, 竹内実]
通讯作者: 竹内実
Hotwater extract of Agaricus blazei Murill (ABM) prevents the ageing process by activation of neutrophil functions
姬松茸热水提取物 (ABM) 通过激活中性粒细胞功能来预防衰老过程
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Mayuko Miyagawa, Ayaka Kawazoe, Eri Shigeyosi, Yuriko Hirono, Sakura Masaaki ,Toru Takeuchi, K.E.Pinkerton, Minoru Takeuchi]
通讯作者: Minoru Takeuchi
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Mayuko Miyagawa, Shinichi Inoue, Hirono Yuriko, Takahiro Ishida, Masaaki Sakura, Toru Takeuchi, Yuichi Hoshishima, Kent E.Pinkerton, Minoru Takeuchi]
通讯作者: Minoru Takeuchi
Repair of DNA Damage in Alveolar Macrophages Induced by Cigarette Smoke Exposure.
香烟烟雾暴露引起的肺泡巨噬细胞 DNA 损伤的修复。
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Yuriko Hirono, Shinichi Inoue, Mayuko Miyagawa, Takahiro Ishida, Sumire Inaga, Tomonori Naguro, Osamu Mazda, Sonoko Nagai, Toru Takeuchi, K.E.Pinkerton, Minoru Takeuchi]
通讯作者: Minoru Takeuchi
42
    Effect of smoking on alveolar macrophage and pathogenesis of allergy
    • 批准号:
      17K01807
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.91万
    • 财政年份:
      2017
    • 负责人:
      TAKEUCHI Minoru
    • 依托单位:
    Effect of smoking on alveolar macrophage and pathogenesis of allergy
    • 批准号:
      26350852
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.16万
    • 财政年份:
      2014
    • 负责人:
      TAKEUCHI Minoru
    • 依托单位:
    Effect of passive smoking on chromosome aberration and DNA damage in alveolar macrophage
    • 批准号:
      23500826
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.33万
    • 财政年份:
      2011
    • 负责人:
      TAKEUCHI Minoru
    • 依托单位:
    Effect of smoking on DNA damage and chromosome aberration in alveolar macrophage
    • 批准号:
      17500488
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.4万
    • 财政年份:
      2005
    • 负责人:
      TAKEUCHI Minoru
    • 依托单位:
    海外基金