Long-term voluntary exercise improves the efficacy of cerebral angiogenesis and neurogenesis in stroke-prone genetically hypertensive rats

长期自主运动可改善脑卒中遗传性高血压大鼠脑血管生成和神经发生的功效

• 批准号: 20500636
• 负责人: NIWA Atsuko
• 金额: $ 3.08万
• 依托单位: Kinki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20500636/
• 关键词: 運動処方と運動療法; 脳血管障害; 血管内皮前駆細胞; 血管新生; 神経新生; 脳卒中; SHRSP; 運動習慣; 神経幹細胞; 機能回復; 造血幹細胞; 運動; 血管発生

Beneficial effects of long-term exercise (EX) may relate to increase endothelial and hematopoietic progenitors, and neuronal stem cells. In EX SHRSP, the number and activity of EPC and hematopoietic cells in bone marrow and peripheral blood cells were increased before and after stroke. The numbers of microvessels and neuronal stem cells around cerebral lesion were increased in EX, coincident with the appearance of EPC. Furthermore, levels of CXCL12, VEGF, and BDNF were higher in the plasma and cerebral homogenates of EX rats than sedentary rats and the signaling molecules, ERK and CREB, were also up-regulated in EX rats.

长期运动（EX）的有益作用可能与增加内皮和造血祖细胞以及神经干细胞有关。在EX SHRSP中，中风前后骨髓和外周血细胞中的EPC和造血细胞的数量和活性增加。EX组病变周围微血管和神经干细胞数量增多，与EPC的出现相一致。此外，EX大鼠血浆和脑组织匀浆中CXCL12、VEGF和BDNF的水平高于久坐大鼠，并且信号分子ERK和CREB在EX大鼠中也上调。