Metal-catalyzed cross-coupling reaction between aryl and fluorofunctional groups by using strong electron-poor ligand

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Metal-catalyzed coupling reaction between aryl and fluorofunctional group was studied. Firstly, we investigated the electronic effect of supporting ligand on reductive elimination of biaryl. As a result, we found that the strong electron-poor diphosphine ligand accelerated reductive elimination of biaryl. Secondly, we tried the reductive elimination of aryl and fluorofunctional group from palladium catalyst bearing strong electron-poor ligand. However, the complex was decomposed before reductive elimination at high reaction temperature.