Development of Molecular Catalysts Having a Dockable Part for Asymmetric Bond Activations

为了开发两个有机反应、不对称转化和键活化相结合的反应体系的新型分子催化剂，我们设计了Ind-PO配体和Ind-NHC配体，其中吲基和氧膦基团通过亚烷基连接，吲基和N-杂环碳部分通过乙烯链连接，并制备了具有平面手性和金属中心手性等多种手性的Ir络合物。我们还证明了它们对分子内C-H键活化的反应性和不对称烯丙化反应的催化活性。

In order to develop novel molecular catalysts for reaction systems created by combining two organic reactions, asymmetric transformations and bond activations, we have designed the Ind-PO ligand, in which the indenyl group and the phosphine oxide group are connected by alkylene chains, and the Ind-NHC ligand, in which the indenyl group and the N-heterocyclicarben part are connected by an ethylene chain, and prepared their iridium complexes having several chiralities such as the planar chirality on the indenyl ring and a metal-centered chirality. We also demonstrated their reactivity for intramolecular C-H bond activations and catalytic activities for asymmetric allylations.