Genetic studies of cell proliferation and growth in Drosophila spermatogenesis

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It has recently been reported that some aspects of cell division and cell growth in germ line cells are different from those in somatic cells. Our genetic analysis of insulin-like peptides, insulin receptor and its signal transducers revealed that the insulin signal induces both division of male germline stem cells and growth of premeiotic spermatocytes. On the other hand, FOXO transcription factor shown as a target of the insulin signaling in somatic cells is not involved in the cell growth but in the germline stem cell division. TOR signaling pathway is also required for the remarkable cell growth of spermatocytes.