The Physiological function of V-ATPase involved in membrane traffick

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Acidification inside membrane compartments is a common feature of all eukaryotic cells. The acidic milieu, generated by the V-ATPase, is involved in many physiological processes including secretion, protein processing, and others. Using subunit-specific knockout mice, we have shown that the function of V-ATPase is involved in insulin secretion, born resorption and macrophage functions. We have also revealed that the (pro)renin receptor functions as an assembly factor of the V-ATPase complex.