Molecular genetics of the development of higher-order brain structures in Drosophila
Molecular genetics of the development of higher-order brain structures in Drosophila
批准号:
20570196
负责人:
FURUKUBO Katsuo
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
The development of brain is a multiple processes consisting of neurogenesis, axon guidance, and the formation of neural layers. Although the Drosophila brain is much simpler than the human brain, its development is under the control of a conserved genetic program that is in common with the development of the vertebrate brain. In this study, we have performed molecular genetic analysis of the development of higher order brain structures, focusing on the mushroom body and the antennal lobe, prominent neural structures in Drosophila. Our study has disclosed novel control mechanisms of axodendritic development that include homeodomain transcription factors and intracellular transport regulators.
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Modeling Schizophrenia in Flies : Direct Expression of a Schizophrenia Susceptibility Gene, DISC1, Impairs Arousal and Associative Learning in Drosophila
果蝇精神分裂症建模:精神分裂症易感基因 DISC1 的直接表达会损害果蝇的觉醒和联想学习
DOI:
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发表时间:
2009
期刊:
影响因子:
--
作者:
[Ando T., Kondoh K., Honjo K., Mochizuki H., Ando M., Horigane S., Takayama K., Maruyama Y., Shimoda M., Kamiya A., Ishida N., Tomoda T., Saitoe M., Sawa A., Furukubo-Tokunaga K.]
通讯作者:
Furukubo-Tokunaga K.
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DOI:
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发表时间:
期刊:
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作者:
[]
通讯作者:
DOI:
10.1523/jneurosci.3848-08.2009
发表时间:
2009-01-14
期刊:
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子:
--
作者:
[Wairkar YP, Toda H, Mochizuki H, Furukubo-Tokunaga K, Tomoda T, Diantonio A]
通讯作者:
Diantonio A
Unc-51/Atg1 Kinase Regulates Kinesin-1 Dependent Axonal Transport and Polarized Axonal Targeting of Diverse Neural Molecules in Drosophila
Unc-51/Atg1 激酶调节果蝇中驱动蛋白-1 依赖性轴突运输和多种神经分子的极化轴突靶向
DOI:
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发表时间:
2009
期刊:
影响因子:
--
作者:
[Mochizuki H., Toda H., Tomoda T., Furukubo-Tokunaga K.]
通讯作者:
Furukubo-Tokunaga K.
Differential induction of short-term and medium-term memories by appetitive and aversive reinforcement in Drosophila larvae
果蝇幼虫食欲和厌恶强化对短期和中期记忆的差异诱导
DOI:
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发表时间:
2008
期刊:
影响因子:
--
作者:
[Honjo K., Tanaka A., Furukubo- Tokunaga K.]
通讯作者:
Furukubo- Tokunaga K.
共 28 条
Molecular genetics of the development of the brain center for learning and memory and its regulatory gene network in Drosophila
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批准号:13440224
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.73万
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财政年份:2001
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负责人:FURUKUBO Katsuo
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依托单位:
海外基金