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Development of vacuole-targeting antifungal chemotherapy for suicide induction

Development of vacuole-targeting antifungal chemotherapy for suicide induction
用于诱导自杀的液泡靶向抗真菌化疗的开发
批准号:
20580083
负责人:
TANAKA Toshio
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
The vacuole-disruptive activities of amphotericin B and polymyxin B were evaluated as novel types of fungicidal actions, and their mechanisms have been partly elucidated. This study also found allicin from garlic and zwiebelan from onion as enhancers of vacuole-targeting fungicidal activities of these antifungal agents, and thus proposes enzymatic production of allicin as a substitute for its production by the chemical reaction. A system has been additionally proposed for practically applying the chemotherapy depending on the vacuole-targeting fungicidal activities.
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会议论文
Salinomycin and citric acid in combination demonstrate bactericidal activity against Gram-negative bacteria.
盐霉素和柠檬酸的组合对革兰氏阴性菌具有杀菌活性。
DOI: --
发表时间: 2009
期刊: Annals Microbiol. Vol.53
影响因子: --
作者: [Ogita, A., Fujita, K., Tanaka, T.]
通讯作者: T.
Enhancement of the funglcidal activity of amphotericin B by allicin : Effects on intracellular ergosterol trafficking
大蒜素增强两性霉素 B 的杀菌活性:对细胞内麦角甾醇运输的影响
DOI: --
发表时间: 2009
期刊: Planta medica 75
影响因子: --
作者: [Ogita, A., Fujita, K., Tanaka, T]
通讯作者: T
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
Alliinase from Ensifer adhaerence and its use for generation of fungicidal activity.
来自 Ensifer Adhaerence 的蒜氨酸酶及其用于产生杀菌活性的用途。
DOI: --
发表时间: 2011
期刊: AMB Express Vol.1
影响因子: --
作者: [Yutani, M., Taniguchi, H., Borjihan, H., Ogita, A., Fujita, K., Tanaka, T.]
通讯作者: T.
26
    Studies on the establishment of sheep production system in less-favored areas
    • 批准号:
      25450410
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.33万
    • 财政年份:
      2013
    • 负责人:
      TANAKA Toshio
    • 依托单位:
    Identification of novel drug targets with Omics-based mechanismsfor obesity treatment
    • 批准号:
      23659136
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.41万
    • 财政年份:
      2011
    • 负责人:
      TANAKA Toshio
    • 依托单位:
    Simplification of furnished cages for laying hens in consideration of their health and comfort, and economical points.
    • 批准号:
      22580314
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.75万
    • 财政年份:
      2010
    • 负责人:
      TANAKA Toshio
    • 依托单位:
    A study on correlation between standards of metabolic syndrome and musculoskeletal indices
    • 批准号:
      20700502
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.83万
    • 财政年份:
      2008
    • 负责人:
      TANAKA Toshio
    • 依托单位:
    海外基金