Development of vacuole-targeting antifungal chemotherapy for suicide induction
Development of vacuole-targeting antifungal chemotherapy for suicide induction
批准号:
20580083
负责人:
TANAKA Toshio
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
The vacuole-disruptive activities of amphotericin B and polymyxin B were evaluated as novel types of fungicidal actions, and their mechanisms have been partly elucidated. This study also found allicin from garlic and zwiebelan from onion as enhancers of vacuole-targeting fungicidal activities of these antifungal agents, and thus proposes enzymatic production of allicin as a substitute for its production by the chemical reaction. A system has been additionally proposed for practically applying the chemotherapy depending on the vacuole-targeting fungicidal activities.
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Salinomycin and citric acid in combination demonstrate bactericidal activity against Gram-negative bacteria.
盐霉素和柠檬酸的组合对革兰氏阴性菌具有杀菌活性。
DOI:
--
发表时间:
2009
期刊:
Annals Microbiol. Vol.53
影响因子:
--
作者:
[Ogita, A., Fujita, K., Tanaka, T.]
通讯作者:
T.
Enhancement of the funglcidal activity of amphotericin B by allicin : Effects on intracellular ergosterol trafficking
大蒜素增强两性霉素 B 的杀菌活性:对细胞内麦角甾醇运输的影响
DOI:
--
发表时间:
2009
期刊:
Planta medica 75
影响因子:
--
作者:
[Ogita, A., Fujita, K., Tanaka, T]
通讯作者:
T
ホームページ等。
主页等
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Alliinase from Ensifer adhaerence and its use for generation of fungicidal activity.
来自 Ensifer Adhaerence 的蒜氨酸酶及其用于产生杀菌活性的用途。
DOI:
--
发表时间:
2011
期刊:
AMB Express Vol.1
影响因子:
--
作者:
[Yutani, M., Taniguchi, H., Borjihan, H., Ogita, A., Fujita, K., Tanaka, T.]
通讯作者:
T.
抗真菌化学療法の新たなターゲットの開拓-出芽酵母をモデルとして-
开发抗真菌化疗新靶点——以酿酒酵母为模型——
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[杉尾剛, 薦田友恵、岡崎夕子、竹田有希、T.M.Taha, 竹内文章, 川崎信治, 荻田亮]
通讯作者:
荻田亮
共 26 条
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Identification of novel drug targets with Omics-based mechanismsfor obesity treatment
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Simplification of furnished cages for laying hens in consideration of their health and comfort, and economical points.
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A study on correlation between standards of metabolic syndrome and musculoskeletal indices
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.83万
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Study on the development of exercise applied Awa-Dance to and function and effect of it.
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批准号:20500597
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Diet treatment by flavonoid for allergic diseases
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依托单位:
Evaluation of condition of health and environment for laying hens : multifactorial comparison of cage and alternative systems
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批准号:19580318
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.66万
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财政年份:2007
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依托单位:
Prediction of onset of allergic diseases through analysis of single nucleotide polymorphisms and prevention of onset of allergic diseases by an appropriate intake of flavonoids
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批准号:17591040
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
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负责人:TANAKA Toshio
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Pharmacoproteomic mechanisms in stress protein expression induction
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批准号:14207003
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$31.62万
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财政年份:2002
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负责人:TANAKA Toshio
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依托单位:
Pharmacogenomics of thyroid disease in molecular target discovery
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批准号:13557221
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.1万
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财政年份:2001
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Analysis of determinants responsible for preferential development of Th2 cells in allergic diseases
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批准号:11670445
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.5万
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财政年份:1999
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负责人:TANAKA Toshio
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依托单位:
The Research about The Application of Cognitive-Behavior Therapy to the Exercise Program Targeted on the Workers with Lifestyle-related Disease
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批准号:10680034
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资助金额:$0.9万
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财政年份:1998
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负责人:TANAKA Toshio
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依托单位:
Genome pharmacology on novel calcium signaling in diseases
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批准号:10044267
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资助金额:$5.44万
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依托单位:
Clinical Therapeutic Research of Calcium Sensitization
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批准号:10470511
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项目类别:Grant-in-Aid for Scientific Research (B)
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财政年份:1998
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负责人:TANAKA Toshio
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依托单位:
Studies on the visual acuity and numerical cognition in dogs using an operant conditioning method
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.66万
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财政年份:1998
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负责人:TANAKA Toshio
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依托单位:
Molecular cell pharmacology on calcium signaling in diseases
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批准号:09044285
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$3.2万
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财政年份:1997
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负责人:TANAKA Toshio
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依托单位:
Active induction of allergen specific Th1 cells for atopic asthma
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批准号:09670475
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.98万
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财政年份:1997
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负责人:TANAKA Toshio
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依托单位:
Novel Molecular Pharmacological Strategy in Clinical Therapeutic Research
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批准号:08557144
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$10.43万
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财政年份:1996
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负责人:TANAKA Toshio
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依托单位:
Molecular cell pharmacology on Novel calcium signaling
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批准号:08044270
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$2.88万
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财政年份:1996
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负责人:TANAKA Toshio
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依托单位:
Ocular surface cell responce to the injury
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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负责人:TANAKA Toshio
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依托单位:
海外基金